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ADASUVE

Phase 1

BiPolar | Small molecule | Psychiatry |Teva Pharmaceutical Industries Limited|Last Updated: Nov 12, 2021

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment30

FDA Designations

No designations recorded

Clinical trial landscape

ADASUVE · 1 trial · 1 indication

Phase 1 1
NCT02184767Study to Assess the Safety and Pharmacokinetics of ADASUVE® at Doses of 2.5, 5, or 10 mg in Children and Adolescents (10 Through 17 Years of Age) With Any Condition Warranting Chronic Use of an Antipsychotic MedicationBiPolar
COMPLETED30 Analytics
PHASE1COMPLETED
Study to Assess the Safety and Pharmacokinetics of ADASUVE® at Doses of 2.5, 5, or 10 mg in Children and Adolescents (10 Through 17 Years of Age) With Any Condition Warranting Chronic Use of an Antipsychotic Medication
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Study Endpoints

Primary Endpoints

area under the plasma concentration-time curve from time 0 to the last measurable concentration (AUC0-t)
48 hours

Secondary Endpoints

area under the plasma concentration-time curve from time 0 to infinity (AUC0-inf)
48 hours
ratio of AUC0-t to AUC0-inf (AUC0-t/AUC0-inf)
48 hours
maximum observed plasma drug concentration (Cmax)
48 hours
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeOTHER

Treatment Arms

ArmTypeDescription
ADASUVE®EXPERIMENTALoral inhalation using a single-use, hand-held, inhaler; dosage determined by the investigator according the participants weight

Interventions

NameTypeDescription
ADASUVE®DRUGADASUVE® 2.5, 5, or 10 mg
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Eligibility Criteria

Age Range10 Years to 17 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion 1. Written informed consent is obtained from each patient's parent or legal guardian and written assent is obtained from each patient. 2. The patient is a boy or girl 10 through 17 years of age. 3. The patient is within the 2.5 to 97.5 percentile for body mass index (BMI) on the basis of ...

Countries:United States
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Frequently asked questions about ADASUVE

What is ADASUVE used for in bipolar disorder?

ADASUVE is an investigational small molecule being studied for use in bipolar disorder. It is being evaluated in children and adolescents aged 10 through 17 years with any condition warranting chronic use of an antipsychotic medication, including bipolar disorder. The drug is in Phase 1 clinical development and is not yet approved.

Who makes ADASUVE?

ADASUVE is being developed by Teva Pharmaceutical Industries Limited, which trades under the ticker TEVA. The company is conducting clinical trials to evaluate the safety and pharmacokinetics of ADASUVE in pediatric patients with conditions such as bipolar disorder.

What phase is ADASUVE in?

ADASUVE is in Phase 1 clinical development. A Phase 1 study has been completed to assess the safety and pharmacokinetics of ADASUVE at doses of 2.5, 5, or 10 mg in children and adolescents aged 10 through 17 years. The drug remains investigational and has not been approved.

What clinical trials is ADASUVE in?

ADASUVE has one completed clinical trial, NCT02184767, which assessed the safety and pharmacokinetics of ADASUVE at doses of 2.5, 5, or 10 mg in children and adolescents aged 10 through 17 years with conditions warranting chronic antipsychotic use, including bipolar disorder. The study enrolled 30 participants in the United States.

How does ADASUVE work?

ADASUVE is a small molecule being developed for psychiatric conditions. Its specific molecular target has not been disclosed in the available information, so its mechanism of action is not described here. The drug is being studied for its safety and pharmacokinetics in pediatric patients.