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ADASUVE

Phase 1

BiPolar | Small molecule | Psychiatry |Teva Pharmaceutical Industries Limited|Last Updated: Nov 12, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment30
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02184767Study to Assess the Safety and Pharmacokinetics of ADASUVE® at Doses of 2.5, 5, or 10 mg in Children and Adolescents (10 Through 17 Years of Age) With Any Condition Warranting Chronic Use of an Antipsychotic MedicationPHASE1 COMPLETED 30Jul 1, 2014May 1, 2015Nov 12, 20212 United States
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Study Endpoints
Primary Endpoints
area under the plasma concentration-time curve from time 0 to the last measurable concentration (AUC0-t)
48 hours
Secondary Endpoints
area under the plasma concentration-time curve from time 0 to infinity (AUC0-inf)
48 hours
ratio of AUC0-t to AUC0-inf (AUC0-t/AUC0-inf)
48 hours
maximum observed plasma drug concentration (Cmax)
48 hours
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeOTHER
Treatment Arms
ArmTypeDescription
ADASUVE®EXPERIMENTALoral inhalation using a single-use, hand-held, inhaler; dosage determined by the investigator according the participants weight
Interventions
NameTypeDescription
ADASUVE®DRUGADASUVE® 2.5, 5, or 10 mg
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Eligibility Criteria
Age Range10 Years — 17 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion 1. Written informed consent is obtained from each patient's parent or legal guardian and written assent is obtained from each patient. 2. The patient is a boy or girl 10 through 17 years of age. 3. The patient is within the 2.5 to 97.5 percentile for body mass index (BMI) on the basis of ...

Countries:United States
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