Recent Updates
Recently added Catalysts

Euthyroid Group

Phase 2

Thyroid Cancer | Small molecule | Oncology |Sanofi|Last Updated: Nov 2, 2018

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedNO_TREATMENT_CONTROLLEDBiomarker
Total Trials1
Total Enrollment63

FDA Designations

No designations recorded

Clinical trial landscape

Euthyroid Group · 1 trial · 1 indication

Phase 2 1
NCT00181168Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid CancerThyroid Cancer
COMPLETED63 Analytics
PHASE2COMPLETED
Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer
Thyroid CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

PET-CT Fusion Scanning Sensitivity
21 Days

PET/CT was performed before (basal PET) and 24-48 h after rhTSH administration (rhTSH-PET) in 63 patients (52 papillary and 11 follicular thyroid cancers). Images were blindly analyzed by two readers. The proposed treatment plan was prospectively assessed before basal PET, after basal PET, and again after rhTSH-PET.

Secondary Endpoints

Increased Fluorodeoxyglucose (FDG) PET Standardized Uptake Value (SUV) After rTSH Specificity
21 Days
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeDIAGNOSTIC

Treatment Arms

ArmTypeDescription
Euthyroid GroupEXPERIMENTALEuthyroid Group: Subjects received rhTSH to prepare for radioiodine therapy.
Hypothyroid GroupNO_INTERVENTIONHypothyroid Group: Thyroid hormone treatment was withheld before radioiodine therapy.

Interventions

NameTypeDescription
Euthyroid GroupDRUGEuthyroid Group: Received rhTSH to prepare for radioiodine therapy.
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria: * Adults (aged ≥ 18 years) with history of treated well-differentiated epithelial thyroid carcinoma (papillary, follicular or Hurthle cell), for which total or near total thyroidectomy plus postoperative radioiodine remnant ablation with 131-I has either been performed or found ...

Countries:United StatesFrance
Unlock Eligibility Criteria

Frequently asked questions about Euthyroid Group

What is Euthyroid Group used for in Thyroid Cancer?

Euthyroid Group is an investigational small molecule being studied for use in Thyroid Cancer. It is currently in Phase 2 clinical development, with one completed trial involving 63 participants. The drug is being developed by Sanofi and has not yet been approved for any use.

Who makes Euthyroid Group?

Sanofi (ticker: SNY) is developing Euthyroid Group. The drug is an investigational small molecule in Phase 2 clinical development for Thyroid Cancer. Sanofi has conducted one completed clinical trial of Euthyroid Group, which enrolled 63 participants.

What phase is Euthyroid Group in?

Euthyroid Group is in Phase 2 clinical development for Thyroid Cancer. It is an investigational drug, meaning it has not been approved by regulatory authorities. The drug has completed one Phase 2 trial, and no active trials are currently listed.

What clinical trials is Euthyroid Group in?

Euthyroid Group has one completed clinical trial, NCT00181168, titled 'Recombinant Thyrotropin PET-CT Fusion Scanning in Thyroid Cancer.' This Phase 2 study enrolled 63 participants in the United States and France, with a minimum age of 18 years. The trial was not blinded and had no treatment control.

Is Euthyroid Group FDA approved?

Euthyroid Group is not FDA approved. It is an investigational drug in Phase 2 clinical development for Thyroid Cancer. The drug has completed one clinical trial, but it remains under investigation and has not received regulatory approval for any indication.