Recent Updates
Recently added Catalysts

R940343

Phase 2

Asthma | Small molecule | Respiratory |Rigel Pharmaceuticals, Inc.|Last Updated: Sep 29, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment301
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01591044A Safety and Efficacy Study of Inhaled R940343 in Patients With Mild to Moderate AsthmaPHASE2 COMPLETED 301Jul 1, 2012Jul 1, 2013Sep 29, 201659 United States, Canada
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Change in FEV1
Baseline and Week 8

Change from baseline in pre-BD FEV1 (% predicted) at Week 8.

Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
R940343 2mg, 2 puffs bidACTIVE_COMPARATORR343 2mg, 2 puffs bid
PlaceboPLACEBO_COMPARATOR -
R940343 1mg, 1 puff bidACTIVE_COMPARATORR343 1mg, 1 puff bid
Interventions
NameTypeDescription
PlaceboDRUG1 puff bid or 2 puffs bid
R940343 1mgDRUGR343 1mg, 1 puff bid
R940343 2mgDRUGR343 2mg, 2 puffs bid
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 70 Years
SexALL
Healthy VolunteersNo
Study Sites59

Inclusion Criteria: * Clinical history of asthma * Ability to perform spirometry Exclusion Criteria: * Chronic obstructive pulmonary disease or bronchiectasis * Upper or lower respiratory infection

Countries:United StatesCanada
Unlock Eligibility Criteria