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RO7851624

Phase 1

Relapsed/Refractory Multiple Myeloma | Small molecule | Oncology |Roche Holding AG|Last Updated: Aug 14, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment160

FDA Designations

No designations recorded

Clinical trial landscape

RO7851624 · 1 trial · 1 indication

Phase 1 1
NCT07558915A Study to Evaluate RO7851624 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)Relapsed/Refractory Multiple Myeloma
RECRUITING160 Analytics
PHASE1RECRUITING
A Study to Evaluate RO7851624 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Relapsed/Refractory Multiple MyelomaUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of Participants With Adverse Events (AEs)
Up to approximately 2 years

Secondary Endpoints

Serum Concentration of RO7851624
Up to approximately 2 years
Objective Response Rate (ORR)
Up to approximately 2 years
Complete Response (CR) Rate/ Stringent Complete Response (sCR) Rate)
Up to approximately 2 years
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
RO7851624EXPERIMENTALParticipants will receive RO7851624 in a dose escalation stage followed by a dose expansion stage.

Interventions

NameTypeDescription
RO7851624DRUGParticipants will receive RO7851624 as per the schedule described in the protocol.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. * Life expectancy of at least 12 weeks. * Diagnosis of multiple myeloma per International Myeloma Working Group (IMWG) criteria. * Measurable disease. Exclusion Criteria: * Treatment with any chemotherap...

Countries:Australia
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Competitive Landscape -Multiple Myeloma 221 trials (matched to "Relapsed/Refractory Multiple Myeloma")

Top 20 of 25 competitors

CompanyTickerTrialsLead PhaseDrugs
AbbVie, Inc.ABBV16PHASE3Pomalidomide, Dexamethasone, Venetoclax
Bristol-Myers Squibb CompanyBMY18PHASE3Iberdomide, Lenalidomide
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK5PHASE3IGI, 10%
GSK plc Sponsored ADRGSK17PHASE3Belantamab mafodotin, Pomalidomide, Dexamethasone, Bortezomib
Johnson & JohnsonJNJ28PHASE3Talquetamab, Pomalidomide, Teclistamab, Elotuzumab, Dexamethasone
Regeneron Pharmaceuticals, Inc.REGN11PHASE3Linvoseltamab, Carfilzomib, Daratumumab, Dexamethasone, Pomalidomide
Pfizer Inc.PFE11PHASE3Elranatamab, Lenalidomide
Sanofi SA Sponsored ADRSNY17PHASE3Isatuximab, Dexamethasone, Pomalidomide, Montelukast, Paracetamol/ Acetaminophen
AstraZeneca PLCAZN5PHASE3AZD0120, Daratumumab, Carfilzomib, Dexamethasone, Bortezomib
Gilead Sciences, Inc.GILD3PHASE3Anitocabtagene Autoleucel, Cyclophosphamide, Fludarabine, Pomalidomide, Bortezomib
Karyopharm Therapeutics, Inc.KPTI6PHASE3Selinexor, Elotuzumab, Pomalidomide, Dexamethasone
Grifols, S.A. Sponsored ADR Class BGRFS1PHASE3Xembify
BioLineRX Ltd. Sponsored ADRBLRX1PHASE3BL-8040/kg, G-CSF
C4 Therapeutics, Inc.CCCC3PHASE2Cemsidomide, Dexamethasone
Cellectar Biosciences, Inc.CLRB1PHASE2Iopofosine I 131 single dose, Iopofosine I 131 fractionated dose
GeoVax Labs, Inc.GOVX1PHASE2COVID-19 Vaccine, Synthetic MVA-based SARS-CoV-2 Vaccine GEO-CM04S1
Autolus Therapeutics Plc Sponsored ADRAUTL1PHASE2AUTO CAR T cell therapy
Incyte CorporationINCY2PHASE1Ruxolitinib, Lenalidomide, Methylprednisolone
Moderna, Inc.MRNA2PHASE1mRNA-2808
BeOne Medicines Ltd. Sponsored ADRONC1PHASE1Sonrotoclax, Dexamethasone, Carfilzomib, Daratumumab, Pomalidomide
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Recent Changes (Last 90 Days)

LOWAug 14, 2026NCT07558915lastUpdatePostDate: changed
LOWAug 14, 2026NCT07558915lastUpdatePostDate: changed
LOWJul 20, 2026NCT07558915lastUpdatePostDate: changed
LOWJul 20, 2026NCT07558915lastUpdatePostDate: changed

Frequently asked questions about RO7851624

What is RO7851624 used for?

RO7851624 is an investigational small molecule being developed for the treatment of relapsed/refractory multiple myeloma (RRMM). It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes RO7851624?

RO7851624 is being developed by Roche Holding AG, a biopharmaceutical company traded on the OTC market under the ticker symbol RHHBY. The drug is currently in Phase 1 clinical trials for relapsed/refractory multiple myeloma.

What phase is RO7851624 in?

RO7851624 is in Phase 1 clinical development. It is an investigational drug being studied in a single active trial for relapsed/refractory multiple myeloma. The drug has not been approved and remains in early-stage clinical testing.

What clinical trials is RO7851624 in?

RO7851624 is being evaluated in a Phase 1 clinical trial with the identifier NCT07558915, titled 'A Study to Evaluate RO7851624 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM).' The trial is currently recruiting participants in Australia and aims to enroll 160 patients aged 18 years and older.

Is RO7851624 FDA approved?

RO7851624 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development for relapsed/refractory multiple myeloma. The drug is being studied in an ongoing clinical trial and has not yet received regulatory approval.