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PF-3463275

Phase 1

Schizophrenia | Small molecule | Psychiatry |Pfizer, Inc.|Last Updated: Oct 2, 2008

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment36

FDA Designations

No designations recorded

Clinical trial landscape

PF-3463275 · 1 trial · 1 indication

Phase 1 1
NCT00567203A Study Of Adjunctive Treatment Of Cognitive Deficits In SchizophreniaSchizophrenia
COMPLETED36 Analytics
PHASE1COMPLETED
A Study Of Adjunctive Treatment Of Cognitive Deficits In Schizophrenia
SchizophreniaUnlock trial analytics

Study Endpoints

Primary Endpoints

Change from baseline in the CNS Vital Signs Cognition Battery composite score
6 days
Safety Endpoints: tolerability, laboratory tests, vital signs, and ECG's.
38 days
Pharmacokinetics of PF-3463275
6 days

Secondary Endpoints

Positive and Negative Syndrome Scale (PANSS)
6 days
Change from baseline in the CNS Vital Signs Cognition Battery domain scores
6 days
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
1EXPERIMENTAL -
2EXPERIMENTAL -
3PLACEBO_COMPARATOR -

Interventions

NameTypeDescription
PF-3463275DRUGPF-3463275 10mg
PlaceboDRUGPlacebo
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Diagnosis of schizophrenia * In stable treatment with risperidone, olanzapine, quetiapine, ziprasidone, aripiprazole, or paliperidone for at least 2 months * Stable symptoms of schizophrenia for at least 3 months. Exclusion Criteria: * Subjects with a psychiatric disorder ot...

Countries:United States
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Frequently asked questions about PF-3463275

What is PF-3463275 used for in schizophrenia?

PF-3463275 is an investigational small molecule being studied as an adjunctive treatment for cognitive deficits in schizophrenia. It was evaluated in a Phase 1 clinical trial in the United States. The drug is not approved and remains in clinical development.

What does PF-3463275 target?

PF-3463275 is a small molecule, but its specific molecular target has not been disclosed. The drug is being investigated for its potential to address cognitive deficits associated with schizophrenia, though the exact mechanism of action is not publicly detailed.

Who is developing PF-3463275?

PF-3463275 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. The company sponsored the clinical trial for this investigational drug.

What phase is PF-3463275 in?

PF-3463275 is in Phase 1 clinical development. It has completed one Phase 1 trial, which was a randomized, double-blind, placebo-controlled study. The drug is investigational and has not been approved by regulatory authorities.

What clinical trials is PF-3463275 in?

PF-3463275 has been studied in one completed clinical trial, identified as NCT00567203. This Phase 1 study, titled 'A Study Of Adjunctive Treatment Of Cognitive Deficits In Schizophrenia,' enrolled 36 participants in the United States and evaluated the drug as an adjunctive treatment.

Is PF-3463275 the same as any other drug?

PF-3463275 is the primary identifier for this investigational drug. No alternative names have been associated with it in the available clinical trial information. It is a distinct small molecule being developed by Pfizer.