Recent Updates
Recently added Catalysts

PF-03893787

Phase 1

Asthma | Small molecule | Respiratory |Pfizer, Inc.|Last Updated: Mar 18, 2010

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment12

FDA Designations

No designations recorded

Clinical trial landscape

PF-03893787 · 2 trials · 2 indications

Phase 1 2
NCT00992342A Phase 1 Study To Evaluate The Safety And Tolerability Of Different Doses Of PF-03893787 In Healthy Adult VolunteersHealthy
COMPLETED36 Analytics
NCT00856687A Study To Assess The Effect Of PF-03893787 On Lung Function Following An Allergen Challenge In Asthmatic SubjectsAsthma
COMPLETED12 Analytics
PHASE1COMPLETED
A Phase 1 Study To Evaluate The Safety And Tolerability Of Different Doses Of PF-03893787 In Healthy Adult Volunteers
HealthyUnlock trial analytics
PHASE1COMPLETED
A Study To Assess The Effect Of PF-03893787 On Lung Function Following An Allergen Challenge In Asthmatic Subjects
AsthmaUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety/toleration: Adverse events, vital signs, 12 lead ECG, blood (including creatine kinase) and urine safety tests and physical examination.
22 days
Spirometry pre- and post- bronchial allergen challenge
2 months

Secondary Endpoints

Pharmacokinetic parameters: Cmax, Tmax, AUCτ, t½, accumulation ratio,
22 days
Laboratory safety tests
2 months
12-lead ECGs
2 months
Unlock Study Endpoints

Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeBASIC_SCIENCE

Treatment Arms

ArmTypeDescription
PF-03893787 5 mgEXPERIMENTAL -
PF-03893787 15 mgEXPERIMENTAL -
PF-03893787 50 mgEXPERIMENTAL -
PF-03893787EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
MontelukastACTIVE_COMPARATOR -

Interventions

NameTypeDescription
PF-03893787DRUGoral solution, 5 mg, QD for 14 days
PlaceboDRUGOral, two doses 12 hours apart
MontelukastDRUGOral, two doses 12 hours apart
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Healthy male subjects and females of non-childbearing potential between the ages of 18 and 55 years. * Body Mass Index (BMI) of 17.5 to 30.5 kg/m\^2; and a total body weight \>50 kg (110 lbs). Exclusion Criteria: * Evidence or history of clinically significant hematological,...

Countries:BelgiumUnited Kingdom
Unlock Eligibility Criteria

Frequently asked questions about PF-03893787

What is PF-03893787 used for?

PF-03893787 is an investigational small molecule being developed by Pfizer for respiratory conditions, specifically studied in asthma and in healthy volunteers. It has been evaluated in Phase 1 clinical trials to assess its effect on lung function following an allergen challenge in asthmatic subjects and to evaluate its safety and tolerability in healthy adults.

Who makes PF-03893787?

PF-03893787 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. The drug is currently in Phase 1 clinical development for respiratory indications.

What phase is PF-03893787 in?

PF-03893787 is in Phase 1 clinical development. It has completed two Phase 1 trials, one in healthy volunteers and one in asthmatic subjects. The drug is investigational and has not been approved by regulatory authorities.

What clinical trials is PF-03893787 in?

PF-03893787 has been studied in two completed Phase 1 trials. NCT00856687 assessed its effect on lung function following an allergen challenge in asthmatic subjects in the United Kingdom. NCT00992342 evaluated the safety and tolerability of different doses in healthy adult volunteers in Belgium.

Is PF-03893787 the same as another drug?

PF-03893787 is the primary name for this investigational compound. No alternative names have been reported for this drug in the available clinical trial information. It is identified solely by its Pfizer code number in the studies.