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NR2B NMDA Antagonist CP-101,606

Phase 2

Parkinson's Disease | Small molecule | Neurology |Pfizer, Inc.|Last Updated: Sep 22, 2006

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindUNCONTROLLED
Total Trials1
Total Enrollment12
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00163085The Effects of an NR2B NMDA Antagonist, CP-101,606, in Patients With Parkinson's DiseasePHASE2 COMPLETED 12May 1, 2005Jan 1, 2006Sep 22, 20061 United States
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Study Endpoints
Primary Endpoints
Dyskinesia Rating Scale
Secondary Endpoints
Fingertapping
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeTREATMENT
Interventions
NameTypeDescription
NR2B NMDA Antagonist CP-101,606 (traxoprodil)DRUG -
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Eligibility Criteria
Age Range30 Years — 80 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * 30- 80-year-old PD patients (UK Parkinson's Disease Brain Bank criteria) with a Hoehn \& Yahr stage score of 2-5 in the "off" state. Exclusion Criteria: * Subjects with evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal...

Countries:United States
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