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apomorphine infusion

Phase 3

Idiopathic Parkinson's Disease | Small molecule | Neurology |Supernus Pharmaceuticals, Inc.|Last Updated: Jun 19, 2025

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment99

FDA Designations

No designations recorded

Clinical trial landscape

apomorphine infusion · 1 trial · 1 indication

Phase 3 1
NCT02339064Infusion of Apomorphine: Long-term Safety StudyIdiopathic Parkinson's Disease
ACTIVE NOT_RECRUITING99 Analytics
PHASE3ACTIVE NOT_RECRUITING
Infusion of Apomorphine: Long-term Safety Study
Idiopathic Parkinson's DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Percent of daily "off" time during the waking day
Baseline Visit to Week 12

Secondary Endpoints

Percent daily "on" time without troublesome dyskinesias during waking day
Baseline Visit to Week 12
Percent of daily "off" time during the waking day
Baseline Visit to Treatment Weeks 2, 4, 8, 20, 28, 36, 44, and 52; and all Treatment Extension Period Visits
Percent of daily "on" time without troublesome dyskinesias during the waking day
Baseline Visit to Treatment Weeks 2, 4, 8, 20, 28, 36, 44, and 52; and all Treatment Extension Period Visits
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Apomorphine infusionEXPERIMENTALContinuous subcutaneous apomorphine infusion

Interventions

NameTypeDescription
apomorphine infusionDRUGTreatment with apomorphine provided by continuous subcutaneous infusion using a portable external electronic pump device
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Eligibility Criteria

Age Range30 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites18

Inclusion Criteria: * Advanced idiopathic PD consistent with UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria * Overall motor control is unsatisfactory in the opinion of the Investigator and subject despite optimized treatment with available therapies, which must include a sta...

Countries:United States
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Recent Changes (Last 90 Days)

LOWAug 1, 2026NCT02339064primaryCompletionDate: changed
LOWAug 1, 2026NCT02339064primaryCompletionDate: changed
LOWAug 1, 2026NCT02339064primaryCompletionDate: changed
LOWMay 24, 2026NCT02339064studyFirstPostDate: changed

Frequently asked questions about apomorphine infusion

What is apomorphine infusion used for?

Apomorphine infusion is used for the treatment of idiopathic Parkinson's Disease. It is a small molecule therapy being developed by Supernus Pharmaceuticals, Inc. (SUPN). The drug is currently in Phase 3 clinical development and is intended to address symptoms associated with this neurological condition.

How does apomorphine infusion work?

Apomorphine infusion is a small molecule that acts as a dopamine receptor agonist. It works by stimulating dopamine receptors in the brain, which helps to compensate for the loss of dopamine-producing neurons that occurs in Parkinson's disease. This mechanism helps to alleviate motor symptoms associated with the condition.

Who makes apomorphine infusion?

Apomorphine infusion is being developed by Supernus Pharmaceuticals, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol SUPN. The company is conducting clinical trials to evaluate the safety and efficacy of this drug for the treatment of idiopathic Parkinson's Disease.

What phase is apomorphine infusion in?

Apomorphine infusion is currently in Phase 3 clinical development. It is an investigational drug, meaning it has not yet been approved by regulatory authorities. The ongoing Phase 3 trial is designed to assess the long-term safety of the infusion in patients with idiopathic Parkinson's Disease.

What clinical trials is apomorphine infusion in?

Apomorphine infusion is being studied in a Phase 3 clinical trial with the identifier NCT02339064, titled 'Infusion of Apomorphine: Long-term Safety Study'. This active, non-recruiting trial has an enrollment of 99 participants and is being conducted in the United States. The study is open to adults aged 30 years and older.

Is apomorphine infusion the same as apomorphine?

Apomorphine infusion is a formulation of apomorphine, a dopamine receptor agonist, delivered via continuous infusion. While apomorphine is the active pharmaceutical ingredient, the infusion formulation is specifically designed for the treatment of idiopathic Parkinson's Disease. The drug is being developed by Supernus Pharmaceuticals under the name apomorphine infusion.