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IMA-026

Phase 1

Asthma | Small molecule | Respiratory |Pfizer, Inc.|Last Updated: Jul 23, 2009

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment24

FDA Designations

No designations recorded

Clinical trial landscape

IMA-026 · 3 trials · 2 indications

Phase 1 3
NCT00725582Study Evaluating the Effect of IMA-026 on Allergen-Induced Late Asthma Response in Mild AsthmaAsthma
COMPLETED24 Analytics
NCT00528099Study Evaluating IMA-026 in Healthy Japanese MalesHealthy
COMPLETED50 Analytics
NCT00517348Study Evaluating IMA-026 in Healthy SubjectsHealthy
COMPLETED50 Analytics
PHASE1COMPLETED
Study Evaluating the Effect of IMA-026 on Allergen-Induced Late Asthma Response in Mild Asthma
AsthmaUnlock trial analytics
PHASE1COMPLETED
Study Evaluating IMA-026 in Healthy Japanese Males
HealthyUnlock trial analytics
PHASE1COMPLETED
Study Evaluating IMA-026 in Healthy Subjects
HealthyUnlock trial analytics

Study Endpoints

Primary Endpoints

Comparison of the maximum change in FEV1 from baseline for the LAR between IMA-026 and placebo
11 weeks
To assess the safety and PK profile of IMA-026 administered as single ascending subcutaneous or intravenous doses.
6 months
Pharmacokinetic (PK) analysis
6 months

Secondary Endpoints

Treatment comparison of the hour 3 and hour 7 FEV1 AUC for the LAR; various comparisons of the methacholine PC20
11 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
AEXPERIMENTAL -
BPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
IMA-026DRUG -
PlaceboOTHER -
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Eligibility Criteria

Age Range18 Years to 60 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: 1. Healthy men and women 18 to 60 yrs with mild allergic asthma 2. only asthma med is short-acting bronchodilator used not more than twice weekly 3. FEV1 greater than 70% predicted and a demonstrated baseline late response to allergen induction Exclusion Criteria: 1. Upper res...

Countries:JapanUnited States
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Frequently asked questions about IMA-026

What is IMA-026 used for?

IMA-026 is an investigational small molecule being studied for use in respiratory conditions. It has been evaluated in clinical trials involving healthy subjects and in patients with mild asthma. The drug is currently in Phase 1 clinical development and is not yet approved for any indication.

Who is developing IMA-026?

IMA-026 is being developed by Pfizer, Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker symbol PFE. The drug is in Phase 1 clinical development for respiratory indications, including asthma.

What phase is IMA-026 in?

IMA-026 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. Clinical trials for IMA-026 have been completed, and the drug is not currently in active clinical trials.

What clinical trials has IMA-026 been in?

IMA-026 has been studied in three completed Phase 1 clinical trials. These include NCT00517348, a study in healthy subjects in the United States, NCT00528099, a study in healthy Japanese males in Japan, and NCT00725582, a study evaluating the effect of IMA-026 on allergen-induced late asthma response in patients with mild asthma.

Is IMA-026 being studied in asthma?

Yes, IMA-026 has been studied in asthma. A completed Phase 1 clinical trial, NCT00725582, evaluated the effect of IMA-026 on allergen-induced late asthma response in patients with mild asthma. The trial enrolled 24 participants aged 18 years and older.

Has IMA-026 been studied in healthy volunteers?

Yes, IMA-026 has been studied in healthy volunteers. Two completed Phase 1 trials, NCT00517348 and NCT00528099, enrolled healthy subjects. The first trial was conducted in the United States with 50 participants, and the second was conducted in Japan with 50 healthy Japanese males.