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ARRY-502, CRTh2 antagonist

Phase 2

Asthma | Small molecule | Respiratory |Pfizer, Inc.|Last Updated: Oct 30, 2023

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment184

FDA Designations

No designations recorded

Clinical trial landscape

ARRY-502, CRTh2 antagonist · 1 trial · 1 indication

Phase 2 1
NCT01561690A Study of ARRY-502 in Patients With Persistent AsthmaAsthma
COMPLETED184 Analytics
PHASE2COMPLETED
A Study of ARRY-502 in Patients With Persistent Asthma
AsthmaUnlock trial analytics

Study Endpoints

Primary Endpoints

Assess the efficacy of the study drug (versus placebo) in terms of prebronchodilator forced expiratory volume in 1 second (FEV1).
6 weeks

Secondary Endpoints

Characterize the safety profile of the study drug in terms of adverse events, clinical laboratory tests, vital signs and electrocardiograms.
6 weeks
Measure the exposure of study drug in terms of plasma concentrations.
6 weeks
Assess the effect of study drug on asthma control in terms of Asthma Control Questionnaire (ACQ) score, the number of symptom-free days and the number of weekly short-acting beta (ß) 2 agonist (SABA) metered dose inhaler (MDI) actuations.
6 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ARRY-502EXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -

Interventions

NameTypeDescription
ARRY-502, CRTh2 antagonist; oralDRUGmultiple dose, single schedule
Placebo; oralDRUGmatching placebo
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Eligibility Criteria

Age Range18 Years to 70 Years
SexALL
Healthy VolunteersNo
Study Sites43

Key Inclusion Criteria: * Documented history of bronchial asthma diagnosed at least 6 months prior to study start and prior to the age of 40 years. * Body mass index (BMI) of 18 to 35 inclusive. * An ACQ score of ≥ 1.5 at specified time points prior to first dose of study drug. * A best prebronchod...

Countries:United States
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Frequently asked questions about ARRY-502, CRTh2 antagonist

What is ARRY-502 used for?

ARRY-502 is an investigational small molecule being studied for the treatment of persistent asthma. It has also been evaluated in healthy subjects as part of early clinical development. The drug is not approved and remains in clinical trials.

Who makes ARRY-502?

Pfizer, Inc. (NYSE: PFE) is developing ARRY-502. The company has sponsored clinical trials of the drug in healthy subjects and in patients with persistent asthma.

What phase is ARRY-502 in?

ARRY-502 is in clinical development. It has completed a Phase 1 trial in healthy subjects and a Phase 2 trial in patients with persistent asthma. The drug is investigational and not approved for any use.

What clinical trials is ARRY-502 in?

ARRY-502 has been studied in two completed trials: NCT01349725, a Phase 1 safety study in healthy subjects, and NCT01561690, a Phase 2 study in patients with persistent asthma. Both trials were conducted in the United States.

Is ARRY-502 the same as any other drug?

No alternative names for ARRY-502 have been disclosed. The drug is referred to solely by its code name ARRY-502 in clinical trial records and by its developer, Pfizer.