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Penumbra System

Phase 2

Stroke | Unknown | Neurology |Penumbra, Inc.|Last Updated: Sep 18, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMC
Total Trials1
Total Enrollment125
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00334061Study to Assess the Safety and Effectiveness of the Penumbra SystemPHASE2 COMPLETED 125Jun 1, 2006Nov 1, 2007Sep 18, 20191 United States
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Study Endpoints
Primary Endpoints
Percentage of Participants With Revascularization of the Occluded Target Vessel
3-Month Post-Procedure

Revascularization is defined by a Thrombolysis in Myocardial Infarction (TIMI) score of 2 or 3 following use of the Penumbra System. TIMI scores are used to describe blood flow at the treated vessel with 0 designating no flow and 3 for normal flow.

Percentage of Participants With Device-related and Procedure-related Serious Adverse Events
3-Month Post-Procedure
Secondary Endpoints
Percentage of Participants With Either a 4-point Improvement on the National Institutes of Health Stroke Scale (NIHSS) at Discharge or a Modified Rankin Scale (mRS) Score of ≤ 2 at 30 Days After Treatment
Discharge or 30-Days Post-Procedure
Percentage of Participants With a Modified Rankin Scale (mRS) Score of ≤ 2 at 90 Days Post Treatment
90-Day
Percentage of Participants With All Cause Mortality
90-Days Post-Treatment
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Interventions
NameTypeDescription
Penumbra SystemDEVICE -
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Eligibility Criteria
Age Range18 Years — 79 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Clinical signs consistent with acute ischemic stroke * 18 to 79 years of age * Neurological deficit resulting in an NIH Stroke Scale (NIHSS) score \> 8 * TIMI 0 or TIMI I flow in vessels accessible to the Penumbra System * Signed informed consent * Present within 8 hours of st...

Countries:United States
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