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Penumbra System

Phase 2

Stroke | Unknown | Neurology |Penumbra, Inc.|Last Updated: Sep 18, 2019

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment125

FDA Designations

No designations recorded

Clinical trial landscape

Penumbra System · 1 trial · 1 indication

Phase 2 1
NCT00334061Study to Assess the Safety and Effectiveness of the Penumbra SystemStroke
COMPLETED125 Analytics
PHASE2COMPLETED
Study to Assess the Safety and Effectiveness of the Penumbra System
StrokeUnlock trial analytics

Study Endpoints

Primary Endpoints

Percentage of Participants With Revascularization of the Occluded Target Vessel
3-Month Post-Procedure

Revascularization is defined by a Thrombolysis in Myocardial Infarction (TIMI) score of 2 or 3 following use of the Penumbra System. TIMI scores are used to describe blood flow at the treated vessel with 0 designating no flow and 3 for normal flow.

Percentage of Participants With Device-related and Procedure-related Serious Adverse Events
3-Month Post-Procedure

Secondary Endpoints

Percentage of Participants With Either a 4-point Improvement on the National Institutes of Health Stroke Scale (NIHSS) at Discharge or a Modified Rankin Scale (mRS) Score of ≤ 2 at 30 Days After Treatment
Discharge or 30-Days Post-Procedure
Percentage of Participants With a Modified Rankin Scale (mRS) Score of ≤ 2 at 90 Days Post Treatment
90-Day
Percentage of Participants With All Cause Mortality
90-Days Post-Treatment
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
Penumbra SystemDEVICE -
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Eligibility Criteria

Age Range18 Years to 79 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Clinical signs consistent with acute ischemic stroke * 18 to 79 years of age * Neurological deficit resulting in an NIH Stroke Scale (NIHSS) score \> 8 * TIMI 0 or TIMI I flow in vessels accessible to the Penumbra System * Signed informed consent * Present within 8 hours of st...

Countries:United States
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Frequently asked questions about Penumbra System

What is the Penumbra System used for in stroke?

The Penumbra System is an investigational medical device being studied for use in stroke. It is designed to remove blood clots from the brain's blood vessels in patients experiencing an acute ischemic stroke. The device is currently in clinical development and has not been approved by the FDA.

Who makes the Penumbra System?

The Penumbra System is developed by Penumbra, Inc., a company publicly traded under the ticker symbol PEN. The company is conducting clinical trials to evaluate the safety and effectiveness of the device for the treatment of stroke.

What phase is the Penumbra System in?

The Penumbra System is in Phase 2 clinical development. A Phase 2 study has been completed to assess its safety and effectiveness in stroke patients. The device is investigational and has not received FDA approval.

What clinical trials is the Penumbra System in?

The Penumbra System has one completed clinical trial, identified as NCT00334061, titled 'Study to Assess the Safety and Effectiveness of the Penumbra System.' This Phase 2 study enrolled 125 participants in the United States and evaluated the device for the treatment of stroke.

Is the Penumbra System FDA approved?

The Penumbra System is not FDA approved. It is an investigational device currently in Phase 2 clinical development. A completed clinical trial has assessed its safety and effectiveness, but regulatory approval has not been granted.