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mometasone furoate dry inhaler

Phase 3

Asthma | Small molecule | Respiratory |Organon & Co.|Last Updated: May 20, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDBiomarker
Total Trials1
Total Enrollment180
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00442117A Comparison of Mometasone Furoate DPI Versus Budesonide DPI in Budesonide DPI in Asthmatics (Study P04880)PHASE3 COMPLETED 180Jun 1, 2007Jul 1, 2009May 20, 2024 -
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Study Endpoints
Primary Endpoints
Mean Percent Change of Forced Expiratory Volume in One Second (FEV1) From Baseline to Week 12.
Baseline and Week 12

FEV1 (forced expiratory volume in one second) measurement at the Baseline visit was compared to the FEV1 measurement during the last visit at Week 12. The mean percent change was calculated.

Secondary Endpoints
Mean Percent Change of FVC (Forced Vital Capacity) From Baseline to Week 12.
Baseline and Week 12
Mean Percent Change of Forced Expiratory Flow (FEF) at (25-75% Interval) From Baseline to Week 12.
Baseline and Week 12
Mean Percent Change of AM PEFR (Peak Exploratory Flow Rate) From Baseline to Week 12.
Baseline and Week 12
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
MF-DPIEXPERIMENTALMF DPI 200 mcg, two puffs once daily PM (total of 400 mcg/day)
BUD-DPIACTIVE_COMPARATORBudesonide (BUD) DPI 200 mcg, two puffs twice daily (total of 800 mcg/day)
Interventions
NameTypeDescription
mometasone furoate dry powder inhalerDRUGMF DPI 200 mcg, two puffs once daily PM (total of 400 mcg/day) for 12 weeks.
Budesonide DPIDRUGBudesonide (BUD) DPI 200 mcg, two puffs twice daily (total of 800 mcg/day) for 12 weeks.
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Eligibility Criteria
Age Range12 Years — N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Subjects must be 12 years of age or older of either gender, who (and their parent/guardian if the subject is under the age of 20) must demonstrate their willingness to sign and write informed consent. * Subjects must have had a history of asthma for at least 6 months. * The su...

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