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QGE031

Phase 2

Atopic Dermatitis | Small molecule | Immunology |Novartis AG|Last Updated: Feb 23, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment22
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01552629A Study Evaluating the Safety and Efficacy of QGE031 in Atopic Dermatitis PatientsPHASE2 COMPLETED 22Jan 5, 2012Aug 28, 2013Feb 23, 20174 Austria, France +1
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Study Endpoints
Primary Endpoints
Change in Eczema Area and Severity Index(EASI)
baseline, 12 weeks

Efficacy response will be assessed using EASI.

Secondary Endpoints
Change in Investigator Global Assessment (IGA) for atopic dermatitis
6 weeks, 12 weeks
Number of participants with adverse events
24 weeks
QGE031 plasma concentrations
24 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Group 1 QGE031EXPERIMENTALQGE031 will be administered as a subcutaneous dose q2 weeks
Group 2 PlaceboPLACEBO_COMPARATORA QGE031 matched placebo will be administered as a subcutaneous dose q2 weeks
Group 3 Cyclosporine AEXPERIMENTALCyclosporine A will be administered (as per label) for atopic dermatitis.
Interventions
NameTypeDescription
QGE031DRUG -
PlaceboDRUG -
Cyclosporine ADRUG -
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites4

Key Inclusion criteria: * Male and female patients 18 to 65 years of age inclusive (at the time of the screening visit), and who passed screening examinations by past medical history, physical examination, vital signs, electrocardiogram, and laboratory tests. * Presence of atopic dermatitis confirm...

Countries:AustriaFranceGermany
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