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Entacapone

Phase 2

Parkinson's Disease | Small molecule | Neurology |Novartis AG|Last Updated: Jan 11, 2024

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment285

FDA Designations

No designations recorded

Clinical trial landscape

Entacapone · 1 trial · 1 indication

Phase 2 1
NCT00237263An Extension Study of Entacapone in Patients With Parkinson's Disease With End-of-dose Wearing-off. This Study is Not Recruiting in the United StatesParkinson's Disease
COMPLETED285 Analytics
PHASE2COMPLETED
An Extension Study of Entacapone in Patients With Parkinson's Disease With End-of-dose Wearing-off. This Study is Not Recruiting in the United States
Parkinson's DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Incidence of adverse events during the long term treatment (maximum 3 years)
Blood pressure at every 12 weeks
Laboratory test at every 16 weeks
ECG at every 16 weeks

Secondary Endpoints

On time based on patient diary (up to 104 weeks)
UPDRS score at every 16 weeks
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
EntacaponeDRUG -
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Eligibility Criteria

Age Range20 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Attended the Phase IIb study * Able to fill out the patient diary Exclusion Criteria: * Serious heart, pulmonary, renal, hepatic or gastrointestinal disease * Dementia symptoms * Pregnant or nursing (lactating) women Other protocol-defined inclusion/exclusion criteria may a...

Countries:United States
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Frequently asked questions about Entacapone

What is Entacapone used for?

Entacapone is used for Parkinson's Disease, specifically for patients experiencing end-of-dose wearing-off. It is a small molecule being developed as a treatment to address motor fluctuations associated with the condition.

Who makes Entacapone?

Entacapone is being developed by Novartis AG, a global healthcare company. Novartis is listed on the stock exchange under the ticker symbol NVS.

What phase is Entacapone in?

Entacapone is in Phase 2 clinical development. It is an investigational drug and has not been approved by regulatory authorities. The drug is being studied to evaluate its effects in patients with Parkinson's Disease.

What clinical trials is Entacapone in?

Entacapone has been studied in a completed Phase 2 clinical trial with the identifier NCT00237263. This trial was an extension study in patients with Parkinson's Disease with end-of-dose wearing-off, enrolling 285 participants in the United States.

Is Entacapone the same as any other drug?

Entacapone is a distinct drug entity. No alternative names have been established for this compound in the available clinical data, and it is referred to solely by its generic name, Entacapone.