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BFH772

Phase 1

Psoriasis | Small molecule | Dermatology |Novartis AG|Last Updated: Mar 28, 2011

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment15

FDA Designations

No designations recorded

Clinical trial landscape

BFH772 · 1 trial · 2 indications

Phase 1 1
NCT00987870Safety and Efficacy of BFH772 in Psoriasis PatientsPsoriasis
COMPLETED15 Analytics
PHASE1COMPLETED
Safety and Efficacy of BFH772 in Psoriasis Patients
PsoriasisUnlock trial analytics

Study Endpoints

Primary Endpoints

Measure: Plaque PASI score
4 weeks

Secondary Endpoints

Measure: Local tolerability
Time Frame: baseline (predose Day 1) and 1h, 3h, 6h after the morning dose, then before each application (morning and evening) until the morning application on Day 5 and then at each visit before the morning application, and at study completion
Measure: BFH772 concentration in plasma
Day 1: Pre-dose; 4h post dose.
Measure: BFH772 concentration in skin
Week 4
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Study Design & Arms

AllocationRANDOMIZED
MaskingTRIPLE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
BFH772 cream 1%EXPERIMENTAL -
Placebo to BFH772 cream 1%PLACEBO_COMPARATOR -
BFH772 ointment 1%EXPERIMENTAL -
Placebo to BFH772 ointmentPLACEBO_COMPARATOR -
calcipotriol/betamethasone ointmentACTIVE_COMPARATOR -

Interventions

NameTypeDescription
BFH772DRUG -
PlaceboDRUG -
calcipotriol/betamethasoneDRUG -
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: * Stable mild to moderate plaque psoriasis (BSA involvement \< 10% or PASI \< 10 * Category "mild to moderate" on PGA as according to the EMEA (CHMP 2004) (Guideline on clinical investigation of medicinal products indicated for the treatment of psoriasis), with or without arthri...

Countries:Germany
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Frequently asked questions about BFH772

What is BFH772 used for?

BFH772 is an investigational small molecule being developed for the treatment of psoriasis, a dermatological condition. It is currently in Phase 1 clinical development and has been studied in patients with psoriasis and arthritis.

Who makes BFH772?

BFH772 is being developed by Novartis AG, a multinational pharmaceutical company traded on the New York Stock Exchange under the ticker symbol NVS. The drug is currently in Phase 1 clinical development for psoriasis.

What phase is BFH772 in?

BFH772 is in Phase 1 clinical development. It is an investigational drug and has not been approved by regulatory authorities. One Phase 1 trial has been completed, involving 15 participants with psoriasis.

What clinical trials is BFH772 in?

BFH772 has been studied in one completed Phase 1 clinical trial, identified as NCT00987870. This trial evaluated the safety and efficacy of BFH772 in patients with psoriasis and arthritis in Germany, with an enrollment of 15 participants.

Is BFH772 FDA approved?

BFH772 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. The completed Phase 1 trial, NCT00987870, was a randomized, double-blind, placebo-controlled study in patients with psoriasis and arthritis.