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V504

Phase 2

Cervical Cancer | Monoclonal antibody | Oncology |Merck & Company, Inc.|Last Updated: Jun 8, 2015

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment620
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00551187A Study to Evaluate Tolerability and Immunogenicity of V504 Administered Concomitantly With GARDASIL (V504-001)(COMPLETED)PHASE2 COMPLETED 620Oct 1, 2007May 1, 2009Jun 8, 2015 -
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Study Endpoints
Primary Endpoints
Geometric mean titers (GMTs) to HPV types contained in the administered vaccines
4 weeks post dose 3
Secondary Endpoints
Seroconversion percentages to HPV types contained in the administered vaccines
4 weeks post dose 3
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
1EXPERIMENTALV504 + Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine
2PLACEBO_COMPARATORPlacebo + Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine
Interventions
NameTypeDescription
V504BIOLOGICALV504 0.5 ml injection in 3 dose regimen for 6 month treatment period.
Comparator: Quadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant VaccineBIOLOGICALQuadrivalent Human Papillomavirus (Types 6, 11, 16, 18) Recombinant Vaccine 0.5 ml injection in 3 dose regimen for 6 month treatment period.
Comparator: Placebo (unspecified)BIOLOGICALV504 Placebo in 3 dose regimen for 6 month treatment period.
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Eligibility Criteria
Age Range16 Years — 26 Years
SexFEMALE
Healthy VolunteersYes

Inclusion Criteria: * Females between 16- to 26-years-old * Has never had Pap testing or has only had normal Pap test results. * Lifetime history of 0 to 4 sexual partners Exclusion Criteria: * History of an abnormal cervical biopsy result * History of a positive test for HPV; History of external...

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Competitive Landscape -Cervical Cancer 68 trials
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