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AB598

Phase 1

Advanced Cancer | Small molecule | Oncology |Arcus Biosciences, Inc.|Last Updated: Jul 1, 2026

Success Probability
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Market & Valuation
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Trial Design
CONTROLLED
Total Trials1
Total Enrollment40
FDA Designations
No designations recorded
Clinical trial landscape

AB598 · 1 trial · 12 indications

Phase 1 1
NCT05891171Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced CancersAdvanced Cancer
ACTIVE NOT_RECRUITING40 Analytics
PHASE1ACTIVE NOT_RECRUITING
Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers
Advanced Cancer
NCT0589117140
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Study Endpoints
Primary Endpoints
Number of Participants with Adverse Events (AEs) and Serious Adverse Events (SAEs)
Up to 2 years
Dose Escalation Cohorts: Number of Participants with Dose-Limiting Toxicities (DLTs)
Up to 2 years
Secondary Endpoints
Area Under the Concentration-Time Curve from Administration ("0") to the Time That the Drug is No Longer Present in the Body ("infinity") (AUC 0-inf) in Whole Blood and Plasma
Predose, Up to 4 hours post dose
Maximum Concentration (Cmax) in Whole Blood and Plasma
Predose, Up to 4 hours post dose
Time to Maximum Concentration (Tmax) in Whole Blood and Plasma
Predose, Up to 4 hours post dose
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Dose Escalation Cohort 1EXPERIMENTALParticipants will receive AB598 intravenous (IV) infusion once every 3 weeks
Dose Escalation Cohort 2EXPERIMENTALParticipants will receive AB598 IV infusion once every 3 weeks
Dose Escalation Cohort 3EXPERIMENTALParticipants will receive AB598 IV infusion once every 3 weeks
Dose Escalation Cohort 4EXPERIMENTALParticipants will receive AB598 IV infusion once every 3 weeks
Pharmacodynamic Cohort 1EXPERIMENTALParticipants will receive AB598 IV infusion once every 3 weeks
Pharmacodynamic Cohort 2EXPERIMENTALParticipants will receive AB598 IV infusion once every 3 weeks
Pharmacodynamic Cohort 3EXPERIMENTALParticipants will receive AB598 IV infusion once every 3 weeks
Dose Expansion Gastric/GEJ Cancer (phase 1b)EXPERIMENTALParticipants will receive AB598 IV infusion every 2 weeks in combination with zimberelimab and FOLFOX (oxaliplatin, leucovorin, fluorouracil)
Interventions
NameTypeDescription
AB598DRUGAdministered as specified in the treatment arm
ZimberelimabDRUGAdministered as specified in the treatment arm
FluorouracilDRUGAdministered as specified in the treatment arm
LeucovorinDRUGAdministered as specified in the treatment arm
OxaliplatinDRUGAdministered as specified in the treatment arm
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Eligibility Criteria
Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites14

Key Inclusion Criteria: * Must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) guidance * Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1 * Prior systemic radiation or whole brain radiation therapy must have been completed at ...

Countries:United StatesAustraliaTaiwan
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Competitive Landscape -Cancer 5 trials (matched to "Advanced Cancer")
CompanyTickerTrialsLead PhaseDrugs
GE Healthcare Technologies Inc.GEHC1PHASE1GEH200520 / GEH200521 - Part A
Zimmer Biomet Holdings, Inc.ZBH1 - Undisclosed
Ascentage Pharma Group International Unsponsored ADRAAPG1PHASE1Olverembatinib
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Recent Changes (Last 90 Days)
LOWJul 2, 2026NCT05891171lastUpdatePostDate: changed
LOWJul 2, 2026NCT05891171lastUpdatePostDate: changed
LOWJul 2, 2026NCT05891171lastUpdatePostDate: changed
LOWJul 2, 2026NCT05891171lastUpdatePostDate: changed
MEDIUMJun 5, 2026NCT05891171primaryCompletionDate: changed
MEDIUMJun 5, 2026NCT05891171primaryCompletionDate: changed
MEDIUMJun 5, 2026NCT05891171primaryCompletionDate: changed
MEDIUMJun 5, 2026NCT05891171primaryCompletionDate: changed
LOWMay 26, 2026NCT05891171primaryCompletionDate: changed
LOWMay 24, 2026NCT05891171studyFirstPostDate: changed