Recent Updates
Recently added Catalysts

LY4065967

Phase 2

Diabetic Peripheral Neuropathic Pain | Small molecule | Neurology |Eli Lilly and Company|Last Updated: Mar 27, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment150
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT07285018A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic PainPHASE2 RECRUITING 150 — — Feb 16, 2026Jul 1, 2027Mar 27, 202637 United States, Puerto Rico
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Change from Baseline in Average Pain Intensity as Measured by the Numeric Rating Scale (NRS)
Baseline, Week 8
Secondary Endpoints
Change From Baseline in the Brief Pain Inventory-Short Form Modified (BPI-SFM) Total Pain Interference Score
Baseline, Week 8
Change from Baseline in Overall Improvement as Measured by Patient's Global Impression of Change (PGI-C)
Baseline, Week 8
Change from Baseline in Worst Pain Intensity as Measured by NRS
Baseline, Week 8
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
LY4065967EXPERIMENTALParticipants will receive LY4065967 orally.
PlaceboPLACEBO_COMPARATORParticipants will receive placebo orally.
Interventions
NameTypeDescription
LY4065967DRUGAdministered orally
PlaceboDRUGAdministered orally
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites37

Inclusion Criteria: * Have presence of diabetic peripheral neuropathy, of symmetrical nature and in lower extremities for ≥6 months and diagnosed by a score of Part B ≥3 on Michigan Neuropathy Screening Instrument (©University of Michigan) * Have a history and current diagnosis of type 1 or type 2 ...

Countries:United StatesPuerto Rico
Unlock Eligibility Criteria
Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT07285018primaryCompletionDate: changed
LOWMay 24, 2026NCT07285018studyFirstPostDate: changed