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LY4006896

Phase 1

Parkinson Disease | Small molecule | Neurology |Eli Lilly and Company|Last Updated: Apr 20, 2026

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment127

FDA Designations

No designations recorded

Clinical trial landscape

LY4006896 · 1 trial · 1 indication

Phase 1 1
NCT06809400A Study of LY4006896 in Healthy Participants and Participants With Parkinson's DiseaseParkinson Disease
RECRUITING127 Analytics
PHASE1RECRUITING
A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease
Parkinson DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Number of Participants with One or More Serious Adverse Event(s) (SAEs) Part A
Baseline to Week 48
Number of Participants with One or More Treatment-Emergent Adverse Events (TEAEs) Part A
Baseline to Week 48
Number of Participants with One or More SAEs Part B
Baseline to Week 61
Number of Participants with One or More TEAEs Part B
Baseline to Week 61

Secondary Endpoints

Pharmacokinetics (PK): Maximum Concentration (Cmax) of LY4006896 ARC-Associated Antisense Part A
Baseline to Week 48
PK: Cmax of LY4006896 ARC-Associated Antisense Part B
Baseline to Week 61
PK: Area Under the Concentration versus Time Curve (AUC) of LY4006896 ARC-Associated Antisense Part A
Baseline to Week 48
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Study Design & Arms

AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part A LY4006896 + PlaceboEXPERIMENTALHealthy participants will receive a single escalating dose of LY4006896 and matching placebo.
Part B LY4006896 + PlaceboEXPERIMENTALParticipants with Parkinson's disease will receive multiple escalating doses of LY4006896 and matching placebo.

Interventions

NameTypeDescription
LY4006896DRUGAdministered intravenously (IV)
PlaceboDRUGAdministered IV
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Eligibility Criteria

Age Range30 Years to 85 Years
SexALL
Healthy VolunteersYes
Study Sites14

Inclusion Criteria: Part A Single Ascending Dose (SAD) and B Multiple Ascending Dose (MAD) * Have a body mass index within the range of 18 to 34 kilogram/square meter (kg/m²) (inclusive). * For Japanese participants: To qualify as a participant of first-generation Japanese origin, the participant,...

Countries:United StatesJapan
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Frequently asked questions about LY4006896

What is LY4006896 used for?

LY4006896 is an investigational small molecule being developed for Parkinson's disease. It is currently in Phase 1 clinical development, with a study enrolling healthy participants and participants with Parkinson's disease. The drug is being studied in the United States and Japan.

Who makes LY4006896?

LY4006896 is being developed by Eli Lilly and Company (NYSE: LLY). The company is conducting a Phase 1 clinical trial of the drug in healthy participants and participants with Parkinson's disease.

What phase is LY4006896 in?

LY4006896 is in Phase 1 clinical development. The drug is being evaluated in an early-stage study that is currently recruiting participants. It is not yet approved and remains investigational.

What clinical trials is LY4006896 in?

LY4006896 is being studied in a Phase 1 trial with the identifier NCT06809400. The trial, titled "A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease," is recruiting 127 participants in the United States and Japan.

Is LY4006896 being studied in healthy volunteers?

Yes, LY4006896 is being studied in healthy volunteers as part of its Phase 1 clinical trial. The study also includes participants with Parkinson's disease, with a minimum age of 30 years for enrollment.