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LY3164530

Phase 1

Neoplasms | Small molecule | Oncology |Eli Lilly and Company|Last Updated: Oct 23, 2019

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment29

FDA Designations

No designations recorded

Clinical trial landscape

LY3164530 · 1 trial · 2 indications

Phase 1 1
NCT02221882A Study of LY3164530 in Participants With CancerNeoplasms
COMPLETED29 Analytics
PHASE1COMPLETED
A Study of LY3164530 in Participants With Cancer
NeoplasmsUnlock trial analytics

Study Endpoints

Primary Endpoints

Recommended Phase 2 Dose of LY3164530: Maximum Tolerated Dose (MTD)
Cycle 1 (Cycle = 28 days)

Recommended Phase 2 Dose of LY3164530: MTD

Secondary Endpoints

Maximum Serum Concentration (Cmax) of LY3164530 Epidermal Growth Factor Receptor (EGFR) Specific ELISA Assay
Cycle 1 predose (Day 1) up to Cycle 6 end of infusion (Day 1)
Maximum Serum Concentration (Cmax) of LY3164530 Mesenchymal-Epithelial Transition Factor (MET) Specific ELISA Assay
Cycle 1 predose (Day 1) up to Cycle 6 end of infusion (Day 1)
Area Under the Serum Concentration-Time Curve (AUC[0-τ]) of LY3164530 EGFR Specific ELISA Assay
Cycle 1 predose (Day 1) up to Cycle 6 end of infusion (Day 1)
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
LY3164530EXPERIMENTALLY3164530 in escalating dose cohorts given intravenously (IV) once on Days 1 and 15 or on Days 1, 8, 15, and 22 of a 28-day cycle. Participants may continue to receive study drug until discontinuation criteria are met.

Interventions

NameTypeDescription
LY3164530DRUGAdministered IV.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites3

Inclusion Criteria * Have advanced or metastatic cancer and be an appropriate candidate for experimental therapy. * Have adequate organ function. * Prior Treatments: * Systemic treatments: Must have discontinued previous systemic treatments for cancer and recovered from the acute effects of ther...

Countries:United States
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Frequently asked questions about LY3164530

What is LY3164530 used for?

LY3164530 is an investigational small molecule being studied for the treatment of neoplasms, including neoplasm metastasis. It is developed by Eli Lilly and Company and is intended for use in oncology. As of the available data, it has completed a Phase 1 clinical trial.

Who makes LY3164530?

LY3164530 is developed by Eli Lilly and Company, a pharmaceutical company listed on the stock exchange under the ticker symbol LLY. The drug is an investigational oncology therapy that has been studied in a Phase 1 clinical trial for the treatment of neoplasms.

What phase is LY3164530 in?

LY3164530 is in Phase 1 of clinical development. It has completed a Phase 1 trial, and there are no active trials currently listed. The drug remains investigational and has not been approved by regulatory authorities.

What clinical trials is LY3164530 in?

LY3164530 has been studied in one clinical trial with the identifier NCT02221882, titled 'A Study of LY3164530 in Participants With Cancer'. This Phase 1 trial was completed and enrolled 29 participants with neoplasms or neoplasm metastasis in the United States.

Is LY3164530 FDA approved?

LY3164530 is not FDA approved. It is an investigational drug that has completed a Phase 1 clinical trial. The drug is still in clinical development and has not been authorized for marketing or use outside of clinical trials.