Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT01524237 | A Study of LY2979165 and LY2140023 in Healthy Volunteers | PHASE1 | COMPLETED | 52 | — | — | Apr 1, 2012 | Jul 1, 2013 | Aug 2, 2013 | 2 | United Kingdom |
| Arm | Type | Description |
|---|---|---|
| 10 mg LY2140023 + ketamine | EXPERIMENTAL | Single oral dose of 10 mg LY2140023 followed by intravenous (IV) ketamine during one of the crossover periods |
| 20 mg LY2979165 + ketamine | EXPERIMENTAL | Single oral dose of 20 mg LY2979165 followed by IV ketamine during one of the crossover periods |
| 40 mg LY2140023 + ketamine | EXPERIMENTAL | Single oral dose of 40 mg LY2140023 followed by IV ketamine during one of the crossover periods |
| 60 mg LY2979165 + ketamine | EXPERIMENTAL | Single oral dose of 60 mg LY2979165 followed by IV ketamine during one of the crossover periods |
| 160 mg LY2140023 + ketamine | EXPERIMENTAL | Single oral dose of 160 mg of LY2140023 followed by IV ketamine during one of the crossover periods |
| Placebo capsules + ketamine | PLACEBO_COMPARATOR | Single oral dose of placebo capsules followed by IV ketamine during one of the crossover periods |
| Placebo tablets + ketamine | PLACEBO_COMPARATOR | Single oral dose of placebo tablets followed by IV ketamine during one of the crossover periods |
| Name | Type | Description |
|---|---|---|
| LY2979165 | DRUG | Capsules administered orally |
| LY2140023 | DRUG | Tablets administered orally |
| Placebo | OTHER | Administered orally |
| Ketamine | OTHER | Administered intravenously (IV) |
Inclusion Criteria: * are overtly healthy, right-handed, Caucasian (non-Hispanic White by self report) males, as determined by medical history and physical examination * agree to use an effective method of birth control during the study and for a period of 3 months after the final dose of study dru...