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CTEV

Phase 2

Coronary Artery Disease | Monoclonal antibody | Cardiovascular |Humacyte, Inc.|Last Updated: Jul 28, 2026

Target and mechanism

ModalityMonoclonal antibody

Also known as Humacyte Coronary Tissue Engineered Vessel (CTEV), Humacyte Coronary Tissue Engineered Vessel

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment10

FDA Designations

No designations recorded

Clinical trial landscape

CTEV · 1 trial · 1 indication

Phase 2 1
NCT07730528Study to Evaluate the Safety and Efficacy of Humacyte's Coronary Tissue Engineered Vessel (CTEV) in Patients With Coronary Artery Disease Requiring Coronary Artery Bypass Grafting (CABG)Coronary Artery Disease
NOT YET_RECRUITING10 Analytics
PHASE2NOT YET_RECRUITING
Study to Evaluate the Safety and Efficacy of Humacyte's Coronary Tissue Engineered Vessel (CTEV) in Patients With Coronary Artery Disease Requiring Coronary Artery Bypass Grafting (CABG)
Coronary Artery DiseaseUnlock trial analytics

Study Endpoints

Primary Endpoints

Rate of events (MACE, AE, AESI, etc.) in all participants implanted with CTEV
36 months

Secondary Endpoints

Graft patency at month 2 assessment among all implanted grafts
2 Months
Graft patency at month 6 assessments among all implanted grafts
6 months
Graft patency at month 12 assessments among all implanted grafts
12 Months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Humacyte Coronary Tissue Engineered Vessel (CTEV)EXPERIMENTALSurgically implanted CTEV for CABG

Interventions

NameTypeDescription
Humacyte Coronary Tissue Engineered Vessel (CTEV)BIOLOGICALThe CTEV is a tissue-engineered acellular vascular conduit regulated as a biological product by the Food and Drug Administration (FDA). The CTEV has an inner diameter of 3.5 mm and with approximately 20 cm of usable length.
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo

Inclusion Criteria: 1. Age ≥18 years with the ability to provide written informed consent. 2. Planned first isolated CABG surgery for atherosclerotic coronary artery disease with a planned LIMA graft to the LAD and at least one other planned vessel bypass. 3. An RCA or LCx territory target vessel f...

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Recent Changes (Last 90 Days)

LOWJul 28, 2026NCT07730528NEW_TRIAL: changed
LOWJul 28, 2026NCT07730528NEW_TRIAL: changed