Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT06506266 | Study of the Effect of HFA-152a and HFA-134a Propellants on Mucociliary Clearance in Healthy Participants | PHASE1 | COMPLETED | 24 | — | — | Jul 29, 2024 | Oct 24, 2024 | Apr 14, 2026 | 1 | United Kingdom |
\[AUC(0-4h)\] was assessed for Mucociliary clearance (MCC) in participants following administration of nebulized 99mTc on Day 7. Gamma scintigraphy was utilized to conduct assessments.
| Arm | Type | Description |
|---|---|---|
| HFA-152a followed by HFA-134a | EXPERIMENTAL | - |
| HFA-134a followed by HFA-152a | EXPERIMENTAL | - |
| Name | Type | Description |
|---|---|---|
| HFA-152a | OTHER | HFA-152a is administered via oral inhalation |
| HFA-134a | OTHER | HFA-134a is administered via oral inhalation |
| Radiolabeled saline solution | OTHER | Radiolabeled saline solution is administered via oral inhalation |
Inclusion Criteria: Participants are eligible to be included in the study only if all following criteria apply: * Male or Female, age 30 to 55 years * Body Mass Index (BMI): 18.0 to 32.0 kg/m2, inclusive, at screening * Weight: ≥50 kg * Nonsmokers or ex-smokers for more than 6 months with a smokin...