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FLOVENT HFA

Phase 1

Asthma | Small molecule | Respiratory |GSK plc|Last Updated: Sep 11, 2017

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment16
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00370097FLOVENT Hydrofluoroalkane (HFA) In 6-12 Month Old SubjectsPHASE1 COMPLETED 16Aug 30, 2006Apr 12, 2007Sep 11, 20177 United States
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Study Endpoints
Primary Endpoints
Serum cortisol weighted mean(0-12h)
throughout the study
Secondary Endpoints
Serum cortisol Cmin FP Cmaxss, AUClast and tmaxss Adverse events
throughout the study
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Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Subjects receiving HFAEXPERIMENTALSubjects in Session 1 will receive two inhalations of placebo HFA by meter-dose inhaler (MDI) twice daily and in Session 2 subjects will receive two inhalations of fluticasone propionate (FP) HFA MDI 44 mcg twice daily
Interventions
NameTypeDescription
FLOVENT (fluticasone propionate) HFADRUGFLOVENT HFA consists of a white to off-white suspension of FP (micronized) in a liquefied hydrofluoroalkane propellant, 1,1,1,2-tetrafluoroethane. Subject will receive FP HFA using an Aerochamber Plus with Infant Mask.
Placebo HFADRUGSubjects will receive FP-matched placebo using an Aerochamber Plus with Infant Mask.
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Eligibility Criteria
Age Range6 Months — 12 Months
SexALL
Healthy VolunteersNo
Study Sites7

Inclusion Criteria: * Subjects who have experienced 2 or more wheezing episodes in the previous 6 months. * Subjects may not have taken any corticosteroids in the 4 weeks prior to dosing * Parents/guardians should be able to read and comprehend diary information collected throughout the study * Par...

Countries:United States
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