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PIPE-791 Dose A

Phase 2

Idiopathic Pulmonary Fibrosis | Small molecule | Respiratory |Contineum Therapeutics, Inc.|Last Updated: Jul 23, 2026

Success Probability
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDDMC
Total Trials1
Total Enrollment324
FDA Designations
No designations recorded
Clinical trial landscape

PIPE-791 Dose A · 1 trial · 1 indication

Phase 2 1
NCT07284459Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary FibrosisIdiopathic Pulmonary Fibrosis
RECRUITING324 Analytics
PHASE2RECRUITING
Study to Evaluate the Efficacy, Safety, and Tolerability of PIPE 791 in Subjects With Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary FibrosisUnlock trial analytics
Study Endpoints
Primary Endpoints
Absolute change in forced vital capacity (FVC) (mL)
From baseline to Week 26
Secondary Endpoints
To investigate the safety and tolerability of PIPE-791 compared to placebo based on percentage of treatment-emergent adverse events (TEAE)
From baseline to Week 30
Relative change in FVC (mL)
From baseline to Week 26
Proportion of participants with a ≥10% absolute decline in percent predicted FVC (ppFVC)
From baseline to Weeks 12 and Week 26
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Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
PIPE-791 Dose AEXPERIMENTAL -
PIPE-791 Dose BEXPERIMENTAL -
PlaceboPLACEBO_COMPARATOR -
Interventions
NameTypeDescription
PIPE-791 Dose ADRUGParticipants will receive a daily oral dose of PIPE-791 in tablet form
PIPE-791 Dose BDRUGParticipants will receive a daily oral dose of PIPE-791 in tablet form
PlaceboDRUGParticipants will receive a daily oral dose of matching Placebo in tablet form
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Eligibility Criteria
Age Range40 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites53

Key Inclusion Criteria: * Male or female ≥ 40 years of age at the time of Randomization. * A diagnosis of IPF within 7 years prior to Screening, based on the 2022 ATS/ERS/JRS/ALAT practice guideline as confirmed by the Investigator, and a centrally read screening HRCT consistent with usual intersti...

Countries:ArgentinaAustraliaCanadaIsraelNew ZealandSerbiaSouth KoreaUnited Kingdom
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Recent Changes (Last 90 Days)
LOWJul 24, 2026NCT07284459lastUpdatePostDate: changed
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LOWJun 29, 2026NCT07284459lastUpdatePostDate: changed
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LOWJun 25, 2026NCT07284459lastUpdatePostDate: changed