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PROMUS Element Plus, SYNERGY

Phase 3

Coronary Artery Disease | Unknown | Cardiovascular |Boston Scientific Corporation|Last Updated: Jan 30, 2019

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment1,684
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01665053The EVOLVE II Clinical Trial To Assess the SYNERGY Stent System for the Treatment of Atherosclerotic Lesion(s)PHASE3 COMPLETED 1,684Nov 1, 2012Dec 22, 2018Jan 30, 2019126 United States, Australia +14
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Study Endpoints
Primary Endpoints
Percentage of Participants With Target Lesion Failure (TLF) at 12 Months
12 months

TLF is defined as any ischemia-driven revascularization of the target lesion, myocardial infarction (Q-wave and non-Q-wave) related to the target vessel, or cardiac death.

Secondary Endpoints
Percentage of Participants With Target Lesion Revascularization (TLR) at 12 Months.
12 months
Percentage of Participants With Target Vessel Revascularization (TVR) at 12 Months.
12 months
Percentage of Participants With Target Vessel Failure (TVF) at 12 Month.
12 months
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Study Design & Arms
AllocationRANDOMIZED
MaskingSINGLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Promus Element PlusACTIVE_COMPARATORPROMUS Element Plus is a device/drug combination product composed of two components, a device (coronary stent system including a platinum chromium stent platform) and a drug product (a formulation of everolimus contained in a polymer coating).
SYNERGYEXPERIMENTALSYNERGY is a device/drug combination product composed of two components, a device (coronary stent system including a platinum chromium stent platform) and a drug product (a formulation of everolimus contained in a bioabsorbable polymer coating).
Interventions
NameTypeDescription
PROMUS Element PlusDEVICEA drug eluting coronary stent system
SYNERGYDEVICEA drug eluting coronary stent system
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites126

Inclusion Criteria: * Subject must be at least 18 years of age * Subject (or legal guardian) understands the trial requirements and the treatment procedures and provides written informed consent before any trial-specific tests or procedures are performed * For subjects less than 20 years of age enr...

Countries:United StatesAustraliaAustriaBelgiumCanadaDenmarkFinlandFranceItalyJapanLatviaNetherlandsNew ZealandPolandSingaporeSpain
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