Approval Probability
TA Base Rate
Adjusted LOA
ML Risk
Interacting drugs- Cooperstown Cocktail · 1 trial · 1 indication
| Arm | Type | Description |
|---|---|---|
| A | OTHER | - |
| B | EXPERIMENTAL | - |
| C | EXPERIMENTAL | \+ Other |
| Name | Type | Description |
|---|---|---|
| Interacting drugs - Cooperstown Cocktail (midazolam, warfarin, (+ vitamin K), caffeine, omeprazole and dextromethorphan) | DRUG | Capsules + Tablets + Oral solution, Oral, Midazolam: 5 mg, Warfarin: 10 mg (vitamin K 10 mg), caffeine: 200 mg, omeprazole: 40 mg, dextromethorphan: 30 mg once daily, Day 1, 1 Day |
| BMS-708163 | DRUG | Capsules, Oral, 150 mg, once daily, days 6-15, 10 Days |
| BMS-708163 + Cooperstown Cocktail | DRUG | Capsules + tablets + Oral solution, Oral, BMS-708163: 150 mg + Midazolam: 5 mg, Warfarin: 10 mg (vitamin K 10 mg), caffeine: 200 mg, omeprazole: 40 mg, dextromethorphan: 30 mg, BMS-708163, once daily, days 16-20 midazolam,warfarin, (+ vitamin K), caffeine, omeprazole and dextromethorphan once daily on Day 16, 5 Days |
Inclusion Criteria: * Healthy male subjects * 18-45 yrs old inclusive Exclusion Criteria: * Women
Top 20 of 24 competitors