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Mechanism of action of alefacept

Phase 2

Psoriasis | Small molecule | Dermatology |Biogen Inc.|Last Updated: Aug 7, 2008

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDBiomarker
Total Trials1
Total Enrollment9

FDA Designations

No designations recorded

Clinical trial landscape

Mechanism of action of alefacept · 1 trial · 1 indication

Phase 2 1
NCT00150982Alefacept Mechanism of Action in PsoriasisPsoriasis
COMPLETED9 Analytics
PHASE2COMPLETED
Alefacept Mechanism of Action in Psoriasis
PsoriasisUnlock trial analytics

Study Endpoints

Primary Endpoints

To determine if alefacept induces apoptosis in circulating T cells and plaque T cells in psoriasis patients in vivo

Secondary Endpoints

To determine if apoptosis of circulating or plaque T cells in vivo is a better predictor of clinical response than are circulating CD4 T cell counts.
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Study Design & Arms

AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Interventions

NameTypeDescription
Mechanism of action of alefaceptDRUG -
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Eligibility Criteria

Age Range18 Years to N/A
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria * Alefacept is indicated for the treatment of adult patients (18 years or older) with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy. Patients must have at least one plaque of least 2.5 cm in diameter (for biopsies). Exclusion...

Countries:United States
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Frequently asked questions about Mechanism of action of alefacept

What is alefacept used for in psoriasis?

Alefacept is an investigational drug being studied for the treatment of psoriasis. It is currently in Phase 2 clinical development. The drug is being evaluated in patients with psoriasis to understand its mechanism of action. It is not yet approved by the FDA and remains in clinical trials.

Who is developing alefacept?

Alefacept is being developed by Biogen Inc., a biotechnology company traded on the NASDAQ under the ticker symbol BIIB. The company is conducting clinical research on this drug for the treatment of psoriasis. Biogen is responsible for the ongoing development and clinical trials of alefacept.

What phase is alefacept in?

Alefacept is currently in Phase 2 clinical development. It has completed one clinical trial, which was a Phase 2 study. The drug is still investigational and has not been approved by regulatory authorities. Further clinical development may be needed before it can be considered for approval.

What clinical trials has alefacept been in?

Alefacept has been studied in one completed clinical trial with the identifier NCT00150982. This Phase 2 trial was titled "Alefacept Mechanism of Action in Psoriasis" and enrolled 9 participants in the United States. The study was uncontrolled and not randomized or double-blinded, and it included biomarker selection.

Is alefacept the same as any other drug?

Alefacept is a distinct drug candidate being developed by Biogen Inc. for psoriasis. No alternative names for this drug have been established in the available clinical trial information. It is being studied under its own name in the context of its Phase 2 clinical trial.