Recent Updates
Recently added Catalysts

Pulmicort Turbuhaler

Phase 3

Asthma | Small molecule | Respiratory |AstraZeneca PLC|Last Updated: Mar 11, 2011

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
CONTROLLED
Total Trials1
Total Enrollment108
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00855959Study to Evaluate Efficacy and Safety of Pulmicort Respules in Japanese Adult Asthmatic PatientsPHASE3 COMPLETED 108Feb 1, 2009Aug 1, 2009Mar 11, 20116 Japan
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Morning Peak Expiratory Flow (mPEF)
6 weeks

Change in morning peak expiratory flow (mPEF) from baseline (mean of the last 14 days of the period on Pulmicort Turbuhaler) to Week 6 (mean of the last 14 days of the period on Pulmicort Respules)

Secondary Endpoints
Evening Peak Expiratory Flow (ePEF)
6 weeks
Asthma Symptom Score (Daytime); Score of 0-3 (0 = no Asthma Symptoms - 3 = Severe Symptoms)
6 weeks
Asthma Symptom Score (Night-time); Score of 0-3 (0 = no Asthma Symptoms - 3 = Severe Symptoms)
6 weeks
Unlock Study Endpoints
Study Design & Arms
AllocationNON_RANDOMIZED
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALFour weeks treatment with either Pulmicort Turbuhaler at a dose of 400 μg or 200 ug twice daily, followed by 6 weeks treatment with Pulmicort Respules at a dose of 1.0 mg twice daily or 0.5 mg twice daily/1.0 mg once daily
2EXPERIMENTALPulmicort Turbuhaler at a dose of 200 μg twice daily and Pulmicort Respules at a dose of 0.5 mg twice daily or 1.0 mg once daily (low dose)
Interventions
NameTypeDescription
BudesonideDRUGInhalation powder, inhalation, twice daily, 4 weeks followed by Suspension for nebulisation, inhalation, once or twice daily, 6 weeks
Pulmicort TurbuhalerDRUGPulmicort Turbuhaler 200 µg, Dry powder inhaler, budesonide 200 µg/dose, 112 doses/Turbuhaler
Unlock Study Design Details
Eligibility Criteria
Age Range16 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures. * A minimum of 6 months documented history of asthma according to the JGL 2006 definition * Asthma patients under prescribed treatment with ICS at least 3 months before Visit 2. Exclusion Criteria: * Curre...

Countries:Japan
Unlock Eligibility Criteria