Recent Updates
Recently added Catalysts

BDA MDI HFO 160/180 μg

Phase 3

Asthma | Small molecule | Respiratory |AstraZeneca PLC|Last Updated: Feb 13, 2026

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment422
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT06502366A Study to Investigate the Effect on Lung Function of BDA Formulated With a Next Generation Propellant Compared With an Approved Asthma Treatment (BDA With HFA Propellant) in Participants With AsthmaPHASE3 ACTIVE NOT_RECRUITING 422Jul 22, 2024Mar 3, 2026Feb 13, 2026128 United States, China +4
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Change from baseline in peak FEV1 in 0-60 minutes after dosing at Day 29
Change from baseline at Day 29

To assess the equivalence of BDA MDI HFO relative to BDA MDI HFA on lung function in participants with asthma.

Secondary Endpoints
Change from baseline in morning pre-dose trough FEV1
Change from baseline at Day 29
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingQUADRUPLE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
BDA MDI HFOACTIVE_COMPARATOR160/180 µg Budesonide/albuterol pressurized inhalation suspension, HFO
BDA MDI HFAACTIVE_COMPARATOR160/180 µg Budesonide/albuterol pressurized inhalation suspension, HFA
Placebo MDI HFAPLACEBO_COMPARATORPlacebo pressurized inhalation suspension, HFA
Interventions
NameTypeDescription
BDA MDI HFO 160/180 μgDRUGBudesonide/albuterol pressurized inhalation suspension, HFO
BDA MDI HFA 160/180 μgDRUGBudesonide/albuterol pressurized inhalation suspension, HFA
Placebo MDI HFADRUGPlacebo pressurized inhalation suspension, HFA
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites128

Inclusion Criteria: * Participant must be ≥ 18 years of age at the time of signing the ICF. * Participants who have physician diagnosed asthma as defined by GINA for at least 12 months prior to Visit 1. * Eligible participants are on either a) no daily inhaled maintenance therapy or b) daily inhale...

Countries:United StatesChinaMalaysiaMexicoThailandVietnam
Unlock Eligibility Criteria
Recent Changes (Last 90 Days)
LOWMay 26, 2026NCT06502366primaryCompletionDate: changed
LOWMay 24, 2026NCT06502366studyFirstPostDate: changed