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ARR-002

Phase 1

Ovarian Cancer | Small molecule | Oncology |ArriVent BioPharma, Inc.|Last Updated: Sep 3, 2026

Target and mechanism

Molecular targetMUC16/NaPi2b
Target classAntigen
ModalitySmall molecule

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment180

FDA Designations

No designations recorded

Clinical trial landscape

ARR-002 · 1 trial · 5 indications

Phase 1 1
NCT07755436Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of ARR-002 in Advanced or Metastatic Ovarian or Endometrial Cancer.Ovarian Cancer
RECRUITING180 Analytics
PHASE1RECRUITING
Phase 1 Study to Assess Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumor Activity of ARR-002 in Advanced or Metastatic Ovarian or Endometrial Cancer.
Ovarian CancerUnlock trial analytics

Study Endpoints

Primary Endpoints

Treatment-Emergent Adverse Event (TEAE)
Baseline to 30 days after the last dose of study treatment

AEs that occur or worsen on or after the first dose of study treatment

Maximum Tolerated Dose (MTD)
Baseline to Day 21 of the first treatment cycle

Incidence of dose-limiting toxicities (DLTs) and serious adverse events (SAEs)

Secondary Endpoints

Incidence of anti-drug antibody (ADA)
Baseline to 30 days after the last dose.
Objective Response Rate (ORR) - Phase Ia
Baseline to study completion (up to 24 months)
Duration of Response (DOR)
Baseline to study completion (up to 24 months)
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSEQUENTIAL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ARR-002EXPERIMENTAL -

Interventions

NameTypeDescription
ARR-002DRUGARR-002 will be administrated as specified in the protocol.
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Eligibility Criteria

Age Range18 Years to N/A
SexFEMALE
Healthy VolunteersNo
Study Sites6

Inclusion Criteria: * Patients with histologically and cytologically confirmed advanced or metastatic ovarian, primary peritoneal, or fallopian tube cancer, and platinum resistant who have failed or intolerant to standard therapy, or without alternative standard therapy. * Patients must have at lea...

Countries:United States
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Competitive Landscape -Ovarian Cancer 176 trials

Top 20 of 59 competitors

CompanyTickerTrialsLead PhaseDrugs
Merck & Co., Inc.MRK5PHASE3Pembrolizumab, Paclitaxel, Bevacizumab, Docetaxel
AstraZeneca PLCAZN19PHASE3Olaparib
GSK plc Sponsored ADRGSK4PHASE3Niraparib
Eli Lilly and CompanyLLY8PHASE3Sofetabart Mipitecan, Paclitaxel, Topotecan, Gemcitabine, Pegylated liposomal doxorubicin
AbbVie, Inc.ABBV13PHASE3Mirvetuximab soravtansine plus Bevacizumab, Bevacizumab
Bristol-Myers Squibb CompanyBMY4PHASE3Rucaparib, Nivolumab
Genmab A/S Sponsored ADRGMAB5PHASE3Rina-S, Paclitaxel, Topotecan, Pegylated liposomal doxorubicin, Gemcitabine
Pfizer Inc.PFE4PHASE3Avelumab, Lorlatanib, Talazoparib, Pemetrexed, Axitinib
Corcept Therapeutics Incorporated.CORT2PHASE3Nab-paclitaxel/m^2, Relacorilant once daily
Verastem, Inc.VSTM4PHASE3avutometinib, Defactinib, Pegylated liposomal doxorubicin, Paclitaxel, Letrozole
Zentalis Pharmaceuticals, Inc.ZNTL3PHASE3Azenosertib
Imunon, Inc.IMNN3PHASE3IMNN-001, Paclitaxel, Carboplatin, Olaparib, Niraparib
Incyte CorporationINCY2PHASE3INCB123667
Genelux Corp.GNLX1PHASE3olvimulogene nanivacirepvec, Platinum chemotherapy: carboplatin or cisplatin, Non-platinum chemotherapy: Physician's Choice of gemcitabine, taxane or pegylated liposomal doxorubicin, Bevacizumab
Regeneron Pharmaceuticals, Inc.REGN4PHASE2Ubamatamab, Bevacizumab, Cemiplimab, Fianlimab, PLD
Novartis AG Sponsored ADRNVS4PHASE2Dabrafenib, Trametinib
BeOne Medicines Ltd. Sponsored ADRONC2PHASE3Pamiparib
IQVIA Holdings IncIQV1PHASE3Oregovomab, Paclitaxel, Carboplatin
Xencor, Inc.XNCR3PHASE2vudalimab
Exelixis, Inc.EXEL2PHASE2Cabozantinib
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Recent Changes (Last 90 Days)

LOWSep 3, 2026NCT07755436lastUpdatePostDate: changed
LOWSep 3, 2026NCT07755436lastUpdatePostDate: changed
LOWAug 11, 2026NCT07755436NEW_TRIAL: changed
LOWAug 11, 2026NCT07755436NEW_TRIAL: changed
LOWAug 11, 2026NCT07755436NEW_TRIAL: changed

Frequently asked questions about ARR-002

What is ARR-002 used for?

ARR-002 is an investigational small molecule being developed for the treatment of ovarian cancer, including platinum-resistant ovarian cancer and metastatic ovarian cancer. It is also being studied in endometrial cancer. The drug is currently in Phase 1 clinical development and has not been approved by the FDA.

What does ARR-002 target?

ARR-002 targets MUC16 and NaPi2b, which are antigens associated with certain cancers. By targeting these antigens, the drug is designed to interfere with cancer cell activity. This mechanism is being evaluated in a Phase 1 clinical trial for ovarian and endometrial cancers.

Who is developing ARR-002?

ARR-002 is being developed by ArriVent BioPharma, Inc., a biopharmaceutical company traded on the NASDAQ under the ticker symbol AVBP. The company is conducting a Phase 1 clinical trial to assess the safety, tolerability, pharmacokinetics, immunogenicity, and antitumor activity of ARR-002 in patients with advanced or metastatic ovarian or endometrial cancer.

What phase is ARR-002 in?

ARR-002 is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. The ongoing Phase 1 trial is recruiting patients in the United States and is designed to evaluate the drug's safety, tolerability, and preliminary antitumor activity in advanced or metastatic ovarian and endometrial cancers.

What clinical trials is ARR-002 in?

ARR-002 is being studied in a Phase 1 clinical trial with the identifier NCT07755436. This trial is recruiting female patients aged 18 years and older with advanced or metastatic ovarian or endometrial cancer, including platinum-resistant ovarian cancer. The study is uncontrolled, not randomized, and not double-blinded, with a planned enrollment of 180 participants.

Is ARR-002 the same as any other drug?

No alternative names for ARR-002 have been reported. The drug is identified solely as ARR-002 in clinical trial records and by its developer, ArriVent BioPharma, Inc. It is a distinct investigational small molecule being evaluated for the treatment of ovarian and endometrial cancers.