Recent Updates
Recently added Catalysts

Caffeine

Phase 1

Psoriasis | Small molecule | Dermatology |AbbVie Inc.|Last Updated: Sep 25, 2017

Success Probability

Subscribe to view

Market & Valuation

Subscribe to view

Trial Design

UNCONTROLLED
Total Trials1
Total Enrollment21

FDA Designations

No designations recorded

Clinical trial landscape

Caffeine · 1 trial · 1 indication

Phase 1 1
NCT02772601This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic ArthritisPsoriasis
COMPLETED21 Analytics
PHASE1COMPLETED
This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis
PsoriasisUnlock trial analytics

Study Endpoints

Primary Endpoints

AUC0 - tz (area under the concentration-time curve) of caffeine with risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 98-101
AUC0 - tz (area under the concentration-time curve) of caffeine without risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 1-3
AUC0 - tz (area under the concentration-time curve) of warfarin with risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 98 - 105
AUC0 - tz (area under the concentration-time curve) of warfarin without risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 1-8
AUC0 - tz (area under the concentration-time curve) of omeprazole with risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 98 - 100
AUC0 - tz (area under the concentration-time curve) of omeprazole without risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 1-2
AUC0 - tz (area under the concentration-time curve) of metoprolol with risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 98 -100
AUC0 - tz (area under the concentration-time curve) of metoprolol without risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 1-3
AUC0 - tz (area under the concentration-time curve) of midazolam with risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 98 - 99
AUC0 - tz (area under the concentration-time curve) of midazolam without risankizumab in plasma over time interval from 0 to last quantifiable data point
Day 1-2
Cmax (maximum measured concentration) of the analyte omeprazole without risankizumab in plasma
Day 1
Cmax (maximum measured concentration) of the analyte metoprolol with risankizumab in plasma
Day 98
Cmax (maximum measured concentration) of the analyte metoprolol without risankizumab in plasma
Day 1
Cmax (maximum measured concentration) of the analyte midazolam with risankizumab in plasma
Day 98
Cmax (maximum measured concentration) of the analyte midazolam without risankizumab in plasma
Day 1
Cmax (maximum measured concentration) of the analyte caffeine with risankizumab in plasma
Day 98
Cmax (maximum measured concentration) of the analyte caffeine without risankizumab in plasma
Day 1
Cmax (maximum measured concentration) of the analyte warfarin with risankizumab in plasma
Day 98
Cmax (maximum measured concentration) of the analyte warfarin without risankizumab in plasma
Day 1
Cmax (maximum measured concentration) of the analyte omeprazole with risankizumab in plasma
Day 98
Unlock Study Endpoints

Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
All patientsEXPERIMENTAL -

Interventions

NameTypeDescription
CaffeineDRUG -
WarfarinDRUG -
OmeprazoleDRUG -
MetoprololDRUG -
MidazolamDRUG -
RisankizumabDRUG -
Unlock Study Design Details

Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion criteria: * Signed and dated written informed consent in accordance with GCP (Good Clinical Practice) and local legislation prior to admission to the trial and prior to any trial related procedure. * Age 18 years to 75 years at screening * Body mass index of 18.5 to 40.0 kg/m2 and within ...

Countries:Germany
Unlock Eligibility Criteria

Frequently asked questions about Caffeine

What is Caffeine used for in psoriasis?

Caffeine is an investigational small molecule being studied for use in psoriasis. It is currently in Phase 1 clinical development. The drug is being evaluated for its potential effects in patients with psoriasis, with or without psoriatic arthritis.

Who makes Caffeine?

Caffeine is being developed by AbbVie Inc., a biopharmaceutical company traded on the New York Stock Exchange under the ticker ABBV. The company is conducting clinical research to evaluate the drug's safety and effects in patients with psoriasis.

What phase is Caffeine in?

Caffeine is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by regulatory authorities and is still being studied in clinical trials. The Phase 1 trial has been completed.

What clinical trials is Caffeine in?

Caffeine has been studied in one clinical trial, identified as NCT02772601. This Phase 1 study tested the effect of risankizumab on the metabolism of five additional drugs, including caffeine, in patients with psoriasis. The trial was completed in Germany with 21 participants.

Is Caffeine the same as risankizumab?

No, Caffeine is not the same as risankizumab. In clinical trial NCT02772601, caffeine was used as a probe drug to study how risankizumab affects the metabolism of other drugs. Caffeine itself is being investigated as a potential treatment for psoriasis.