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Inactivated COVID-19 Vaccine

Phase 3

COVID-19 | Monoclonal antibody | Infectious Disease |Sinovac Biotech, Ltd|Last Updated: Oct 16, 2023

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment11,349
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT04992260Efficacy, Immunogenicity and Safety of COVID-19 Vaccine , Inactivated in Children and AdolescentsPHASE3 COMPLETED 11,349Sep 10, 2021May 31, 2023Oct 16, 202338 Chile, Malaysia +2
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Study Endpoints
Primary Endpoints
Efficacy index-incidence of RT-PCR confirmed symptomatic COVID-19 cases with onset
14 days after the second dose

Incidence of RT-PCR confirmed symptomatic COVID-19 cases with onset at least 14 days after the second dose

Secondary Endpoints
Efficacy index-incidence of RT-PCR confirmed symptomatic COVID-19 cases with onset
14 days after the first dose
Efficacy index-incidence of RT-PCR confirmed, symptomatic COVID-19 cases with onset in SARS-CoV-2 uninfected participants
14 days after the second dose
Efficacy index-incidence of hospitalization/severe/death caused by COVID-19 with onset
14 days after the second dose
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Experimental GroupEXPERIMENTALsubjects will receive two doses of inactivated COVID-19 vaccine on day 0 and day 28.
Control GroupPLACEBO_COMPARATORsubjects will receive two doses of placebo on day 0 and day 28.
Interventions
NameTypeDescription
Inactivated COVID-19 VaccineBIOLOGICALThe inactivated COVID-19 vaccine was manufactured by Sinovac Research\& Development Co., Ltd..600SU Inactivated SARS-COV-2 virus in 0·5 mL of aluminium hydroxide solution per injection
Controlled vaccineBIOLOGICALThe placebo was manufactured by Sinovac Research\& Development Co., Ltd.The composition is aluminium hydroxide,The appearance of the placebo is consistent with the vaccine, which is a milky-white suspension.
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Eligibility Criteria
Age Range6 Months — 17 Years
SexALL
Healthy VolunteersYes
Study Sites38

Inclusion Criteria: * Healthy children and adolescents aged 6 months to 17 years; * The participants and/or their guardians are able to understand and sign the informed consent voluntarily (in accordance with the local regulations); * Able to comply with study procedures based on the assessment of ...

Countries:ChileMalaysiaPhilippinesSouth Africa
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