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SAR292833

Phase 2

Neuropathic Pain | Small molecule | Neurology |Sanofi|Last Updated: Feb 26, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment191
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01463397Efficacy and Safety of SAR292833 Administration for 4 Weeks in Patients With Chronic Peripheral Neuropathic PainPHASE2 COMPLETED 191Mar 1, 2012May 1, 2013Feb 26, 201661 United States, Czechia +5
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Study Endpoints
Primary Endpoints
Change from baseline in the average daily pain intensity as measured by the 11-point NRS;
Baseline to 4 weeks

The average daily pain intensity is the mean of the last consecutive 7 days.

Secondary Endpoints
Percentage of patients with reduction in pain intensity of at least 30% and 50% at endpoint compared to baseline derived from the primary efficacy endpoint;
Baseline to 4 weeks
Change in Neuropathic Pain Symptom Inventory (NPSI) after 4 weeks treatment compared to baseline
Baseline to 4 weeks
Change in intensity of the mechanical allodynia after 4 weeks treatment compared to baseline using visual analog scale (VAS)
Baseline to 4 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
SAR292833 dose level 1EXPERIMENTALDose level 1 twice daily immediately after breakfast/dinner
SAR292833 dose level 2EXPERIMENTALDose level 2 twice daily immediately after breakfast/dinner
PlaceboPLACEBO_COMPARATORPlacebo (for SAR292833) twice daily immediately after breakfast/dinner
Interventions
NameTypeDescription
SAR292833DRUGPharmaceutical form: capsule Route of administration: oral
placeboDRUGPharmaceutical form:capsule Route of administration: oral
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Eligibility Criteria
Age Range18 Years — 85 Years
SexALL
Healthy VolunteersNo
Study Sites61

Inclusion criteria: -The study will include adult patients of either gender, 18 - 85 of age, who have signed the informed consent form, and presenting with chronic peripheral neuropathic pain associated with: diabetic polyneuropathy, post-herpetic neuralgia. * The neuropathic pain must have a dist...

Countries:United StatesCzechiaHungaryPolandRussiaSlovakiaUkraine
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