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NVX-CoV2705

Phase 3

COVID-19 | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Jun 5, 2026

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment676

FDA Designations

No designations recorded

Clinical trial landscape

NVX-CoV2705 · 1 trial · 2 indications

Phase 3 1
NCT07079670Safety and Immunogenicity of NVX-CoV2705COVID-19
COMPLETED676 Analytics
PHASE3COMPLETED
Safety and Immunogenicity of NVX-CoV2705
COVID-19Unlock trial analytics

Study Endpoints

Primary Endpoints

Pseudovirus neutralization (ID50) of Omicron JN.1 subvariant vaccine expressed as GMFR
Day 28

Pseudovirus neutralization (ID50) GMFR for the Omicron JN.1 subvariant at Day 28 following study vaccination.

Secondary Endpoints

Pseudovirus neutralization (ID50) of Omicron JN.1 subvariant vaccine expressed as GMT
Day 28
Pseudovirus neutralization (ID50) of Omicron JN.1 subvariant vaccine expressed as SRR
Day 28
Number of Participants Reported Solicited Local and Systemic Adverse Events (AEs)
Day 28
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposePREVENTION

Treatment Arms

ArmTypeDescription
NVX-CoV2705EXPERIMENTALNVX-CoV2705 vaccine in a 0.5 mL injection volume at an antigenic dose of 5 µg with 50 µg Matrix-M adjuvant.

Interventions

NameTypeDescription
NVX-CoV2705BIOLOGICALIntramuscular (deltoid) injection at an antigenic dose of 5 µg with 50 µg Matrix-M adjuvant.
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Eligibility Criteria

Age Range12 Years to 90 Years
SexALL
Healthy VolunteersYes
Study Sites10

Inclusion Criteria: * To be included in this study, each individual must satisfy all the following criteria: 1. Participants ≥ 65 years of age and participants 12 through 64 years who have at least one underlying condition that puts them at high risk of severe outcomes from COVID-19 at time of s...

Countries:United States
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Recent Changes (Last 90 Days)

MEDIUMJul 6, 2026NCT07079670TRIAL_REMOVED: changed
MEDIUMJul 6, 2026NCT07079670TRIAL_REMOVED: changed
MEDIUMJul 6, 2026NCT07079670TRIAL_REMOVED: changed

Frequently asked questions about NVX-CoV2705

What is NVX-CoV2705 used for?

NVX-CoV2705 is an investigational monoclonal antibody being developed for COVID-19, specifically for the prevention or treatment of SARS-CoV-2 infection. It is currently in Phase 3 clinical development and has not been approved by regulatory authorities.

Who makes NVX-CoV2705?

NVX-CoV2705 is being developed by Sanofi, a multinational pharmaceutical company listed on the stock exchange under the ticker symbol SNY. The company is conducting clinical trials to evaluate the safety and immunogenicity of this investigational monoclonal antibody for COVID-19.

What phase is NVX-CoV2705 in?

NVX-CoV2705 is in Phase 3 clinical development. It is an investigational drug and has not yet been approved by regulatory agencies. The Phase 3 trial has been completed, and the drug remains under evaluation for its safety and immunogenicity in the context of COVID-19.

What clinical trials is NVX-CoV2705 in?

NVX-CoV2705 has been studied in one completed Phase 3 clinical trial with the identifier NCT07079670. This trial, titled 'Safety and Immunogenicity of NVX-CoV2705,' enrolled 676 participants in the United States, including healthy volunteers aged 12 years and older, to assess the drug's safety and immune response.

Is NVX-CoV2705 a monoclonal antibody?

Yes, NVX-CoV2705 is a monoclonal antibody, a type of biologic drug designed to target specific proteins. It is being investigated for its potential role in addressing COVID-19 and SARS-CoV-2 infection, though it remains in clinical development and is not yet approved.