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ABY-035

Phase 2

Psoriatic Arthritis | Monoclonal antibody | Other |ACELYRIN, INC.|Last Updated: Feb 9, 2024

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment129
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT04713072A Study to Investigate Efficacy, Tolerability and Safety of ABY-035 in Patients With Active Psoriatic ArthritisPHASE2 COMPLETED 129Aug 4, 2020Jan 27, 2022Feb 9, 202432 Austria, Belgium +5
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Study Endpoints
Primary Endpoints
American College of Rheumatology 50 response rate (ACR50)
16 weeks

ACR50 response rate at V9 (Week 16) for higher Dose vs. Placebo

ACR50
12 weeks

ACR50 response rate at V7 (Week 12) for higher Dose vs. Placebo

Secondary Endpoints
ACR20/70
16 weeks
ACR20/50/70
16 weeks
ACR 20/50/70
8 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingTRIPLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ABY-035 40 mgEXPERIMENTAL40 mg ABY-035 SC
ABY-035 80 mgEXPERIMENTAL80 mg ABY-035 SC
PlaceboPLACEBO_COMPARATORPlacebo, switching to 80 mg ABY-035 after 16 weeks
Interventions
NameTypeDescription
ABY-035BIOLOGICALABY-035 solution for injection
PlaceboBIOLOGICALPlacebo to ABY-035 solution for injection
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Eligibility Criteria
Age Range18 Years — 75 Years
SexALL
Healthy VolunteersNo
Study Sites32

Inclusion criteria: * Patient who has given his / her signed declaration of consent and data protection declaration * At least 18 years and less than 75 years of age at Screening visit * Psoriatic arthritis with inflammatory musculoskeletal disease (joint, spine, or entheseal) with the presence of ...

Countries:AustriaBelgiumCzechiaGermanyHungaryPolandSpain
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