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Secretin

Phase 2

Schizophrenia | Small molecule | Psychiatry |Repligen Corporation|Last Updated: Mar 3, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindUNCONTROLLEDBiomarker
Total Trials1
Total Enrollment30

FDA Designations

No designations recorded

Clinical trial landscape

Secretin · 1 trial · 1 indication

Phase 2 1
NCT00235274Effects of RG1068 (Secretin) on Information Processing in SchizophreniaSchizophrenia
COMPLETED30 Analytics
PHASE2COMPLETED
Effects of RG1068 (Secretin) on Information Processing in Schizophrenia
SchizophreniaUnlock trial analytics

Study Endpoints

Primary Endpoints

Motor learning will be assessed with a classical eye-blink conditioning procedure, requiring the learning of a reflexive eye-blink response to a weak puff of air to the eye.

Secondary Endpoints

Effects of Secretin will be tested on affect modulation, pre-pulse inhibition, and pre-pulse facilitation of the acoustic startle response using common psychophysiological research procedures.
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Interventions

NameTypeDescription
Subcutaneous SecretinDRUG -
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Eligibility Criteria

Age Range18 Years to 55 Years
SexALL
Healthy VolunteersNo
Study Sites1

Inclusion Criteria: 1. Able to give informed consent 2. DSM-IV diagnosis of schizophrenia 3. 18-55 years of age 4. Stable medication \> 4 weeks Exclusion Criteria: 1. Active suicidal ideation 2. Concurrent DSM-IV comorbidity with any substance dependence 3. A urine drug screen that is qualitative...

Countries:United States
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Frequently asked questions about Secretin

What is Secretin used for in schizophrenia?

Secretin is an investigational small molecule being studied for the treatment of schizophrenia. It is being developed by Repligen Corporation (NASDAQ: RGEN). The drug is currently in Phase 2 clinical development, though no active trials are ongoing and the only completed trial has finished.

What does Secretin target?

Secretin is a small molecule being studied for its effects on information processing in schizophrenia. The specific molecular target of Secretin is not disclosed in the available information. The drug is being evaluated for its potential to modulate cognitive processes in patients with schizophrenia.

Who makes Secretin?

Secretin is being developed by Repligen Corporation, a biopharmaceutical company traded on NASDAQ under the ticker symbol RGEN. The company is investigating the drug as a potential treatment for schizophrenia, and it is currently in Phase 2 clinical development.

What phase is Secretin in?

Secretin is in Phase 2 clinical development for schizophrenia. It is an investigational drug, meaning it has not been approved by regulatory authorities. The only clinical trial for Secretin has been completed, and there are no active trials currently enrolling patients.

What clinical trials is Secretin in?

Secretin has been studied in one clinical trial, identified as NCT00235274, titled 'Effects of RG1068 (Secretin) on Information Processing in Schizophrenia'. This Phase 2 trial was completed in the United States and enrolled 30 participants with schizophrenia. The trial was randomized and double-blind, though it had an uncontrolled design.

Is Secretin the same as RG1068?

Yes, Secretin is also known as RG1068. The clinical trial NCT00235274, which studied the drug's effects on information processing in schizophrenia, refers to the drug as RG1068. This alternative name is used in the trial title and is associated with the same investigational compound.