Recent Updates
Recently added Catalysts

MK3207

Phase 1

Migraine Disorders | Small molecule | Neurology |Merck & Company, Inc.|Last Updated: Dec 19, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
Premium
Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
Premium
Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment22
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00548353A Study of Gastric Delay in Migraine Patients (3207-003)PHASE1 COMPLETED 22Aug 1, 2007Feb 1, 2010Dec 19, 2014 -
Unlock Drug Trial Details
Study Endpoints
Primary Endpoints
Safety in migraine patients
12 Weeks
Secondary Endpoints
PK in migraine patients
12 Weeks
Unlock Study Endpoints
Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
1EXPERIMENTALMK3207 Orally administered to patients with water. During each period (with and without acute migraine).
2PLACEBO_COMPARATORMK3207 placebo as tablets will be Orally administered to patients with water. During each period (with and without acute migraine).
Interventions
NameTypeDescription
MK3207DRUGM3207 (20 mg); patients will be administered a single dose of 100 mg of MK3207 (i.e., 5 x20-mg tablets).
Comparator: Placebo (unspecified)DRUGM3207 (20 mg) Pbo; patients will be administered a single dose of 100 mg of MK3207 Pbo (i.e., 5 x20-mg tablets).
Unlock Study Design Details
Eligibility Criteria
Age Range18 Years — 45 Years
SexALL
Healthy VolunteersNo

Inclusion Criteria: * Non-smoking male or female between 18 to 45 years of age * Patient typically has between 2 and 10 migraine attacks per month, rated as moderate or severe Exclusion Criteria: * Patient has any other medical conditions other than migraine

Unlock Eligibility Criteria