Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
| NCT ID | Title | Phase | Status | Enrollment | Velocity | Design | Start | Completion | Last Updated | Sites | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|
| NCT07388667 | A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002) | PHASE1 | ACTIVE NOT_RECRUITING | 120 | — | — | Mar 4, 2026 | Aug 19, 2026 | May 28, 2026 | 5 | United States |
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. The number of participants who experience an AE will be reported.
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. The number of participants who discontinue study treatment due to an AE will be reported.
| Arm | Type | Description |
|---|---|---|
| Panel A: Dose Escalation to Dosage 1 | EXPERIMENTAL | Participants receive escalating doses of oral MK-4082 once daily (QD) or a dose-matched placebo to reach maintenance dose 1. |
| Panel B: Dose Escalation to Dosage 2 | EXPERIMENTAL | Participants receive escalating doses of oral MK-4082 QD or a dose-matched placebo to reach maintenance dose 2. |
| Panel C: Dose Escalation to Dosage 3 | EXPERIMENTAL | Participants receive escalating doses of oral MK-4082 once daily (QD) or a dose-matched placebo to reach maintenance dose 3. |
| Panel D: Dose Escalation to Dosage 4 | EXPERIMENTAL | Participants receive escalating doses of oral MK-4082 once daily (QD) or a dose-matched placebo to reach maintenance dose 4. |
| Panel E: Dose Escalation to Dosage 5 | EXPERIMENTAL | Participants receive escalating doses of oral MK-4082 once daily (QD) or a dose-matched placebo to reach maintenance dose 5. |
| Name | Type | Description |
|---|---|---|
| MK-4082 | DRUG | Oral Tablet |
| Placebo | DRUG | Oral Tablet |
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Is in good health * Has body mass index (BMI) between 25 and 40 kg/m\^2, inclusive. Participants must weigh at least 60 kg Exclusion Criteria: The main exclusion criteria include but are not limited t...