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tadalafil once a day

Phase 3

Erectile Dysfunction | Small molecule | Endocrine |Eli Lilly and Company|Last Updated: Nov 18, 2010

Target and mechanism

ModalitySmall molecule

Also known as tadalafil once a day [T(OaD)]

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment378

FDA Designations

No designations recorded

Clinical trial landscape

tadalafil once a day · 1 trial · 1 indication

Phase 3 1
NCT00734604A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes.Erectile Dysfunction
COMPLETED378 Analytics
PHASE3COMPLETED
A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes.
Erectile DysfunctionUnlock trial analytics

Study Endpoints

Primary Endpoints

Change From Baseline Between Tadalafil Once a Day (OaD) and Sildenafil as Needed (PRN) in Sexual Self-Confidence Domain of Psychological and Interpersonal Relationship Scales (PAIRS)
baseline, 8 weeks of each treatment

The PAIRS is a self-administed scale that assesses the broader psychological and interpersonal outcomes associated with erectile dysfunction and its treatment. Sexual Self-Confidence score is the average of responses on 6 PAIRS item scores. Sexual Self-Confidence scores range from 1 (strongly disagree) to 4 (strongly agree). Higher scores are indicative of greater sexual self-confidence.

Secondary Endpoints

Change From Baseline Between Tadalafil Once a Day (OaD) and Tadalafil as Needed (PRN) in Sexual Self-Confidence Domain of Psychological and Interpersonal Relationship Scales (PAIRS)
baseline, 8 weeks of each treatment
Change From Baseline to Endpoint in the Spontaneity Domain of PAIRS
baseline, 8 weeks of each treatment
Change From Baseline to Endpoint in the Time Concerns Domain of PAIRS
baseline, 8 weeks of each treatment
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
T(OaD)/S(PRN)/T(PRN)EXPERIMENTALTadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks
T(OaD)/T(PRN)/S(PRN)EXPERIMENTALTadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks
S(PRN)/T(OaD)/T(PRN)EXPERIMENTALSildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks
S(PRN)/T(PRN)/T(OaD)EXPERIMENTALSildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks
T(PRN)/T(OaD)/S(PRN)EXPERIMENTALTadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks
T(PRN)/S(PRN)/T(OaD)EXPERIMENTALTadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks

Interventions

NameTypeDescription
tadalafil once a day [T(OaD)]DRUG5 mg tablet taken once a day (OaD) by mouth for 8 weeks
sildenafil citrate as needed [S(PRN)]DRUG100 mg tablet taken as needed (PRN) by mouth for 8 weeks
tadalafil as needed [T(PRN)]DRUG20 mg tablet taken as needed (PRN) by mouth for 8 weeks
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Eligibility Criteria

Age Range18 Years to N/A
SexMALE
Healthy VolunteersNo
Study Sites37

Inclusion Criteria: * History of erectile dysfunction (ED). * Have had satisfactory response to tadalafil, sildenafil citrate, or vardenafil HCl for a period of at least 6 months and expect frequent use (at least one dose per week, on average) when administered as needed. * Have never used tadalafi...

Countries:United StatesAustraliaBrazilGermanyItalyMexicoPuerto RicoSpainUnited Kingdom
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