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Also known as tadalafil once a day [T(OaD)]
tadalafil once a day · 1 trial · 1 indication
The PAIRS is a self-administed scale that assesses the broader psychological and interpersonal outcomes associated with erectile dysfunction and its treatment. Sexual Self-Confidence score is the average of responses on 6 PAIRS item scores. Sexual Self-Confidence scores range from 1 (strongly disagree) to 4 (strongly agree). Higher scores are indicative of greater sexual self-confidence.
| Arm | Type | Description |
|---|---|---|
| T(OaD)/S(PRN)/T(PRN) | EXPERIMENTAL | Tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks |
| T(OaD)/T(PRN)/S(PRN) | EXPERIMENTAL | Tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks |
| S(PRN)/T(OaD)/T(PRN) | EXPERIMENTAL | Sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks |
| S(PRN)/T(PRN)/T(OaD) | EXPERIMENTAL | Sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks |
| T(PRN)/T(OaD)/S(PRN) | EXPERIMENTAL | Tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks |
| T(PRN)/S(PRN)/T(OaD) | EXPERIMENTAL | Tadalafil 20 mg as needed \[T(PRN)\] for 8 weeks, 1 week washout, sildenafil citrate 100 mg as needed \[S(PRN)\] for 8 weeks, 1 week washout, tadalafil 5 mg once a day \[T(OaD)\] for 8 weeks |
| Name | Type | Description |
|---|---|---|
| tadalafil once a day [T(OaD)] | DRUG | 5 mg tablet taken once a day (OaD) by mouth for 8 weeks |
| sildenafil citrate as needed [S(PRN)] | DRUG | 100 mg tablet taken as needed (PRN) by mouth for 8 weeks |
| tadalafil as needed [T(PRN)] | DRUG | 20 mg tablet taken as needed (PRN) by mouth for 8 weeks |
Inclusion Criteria: * History of erectile dysfunction (ED). * Have had satisfactory response to tadalafil, sildenafil citrate, or vardenafil HCl for a period of at least 6 months and expect frequent use (at least one dose per week, on average) when administered as needed. * Have never used tadalafi...
Tadalafil once a day is an oral small molecule therapy being studied for erectile dysfunction. It is a once-daily dosing regimen of tadalafil, developed by Eli Lilly and Company under the ticker LLY. The regimen is intended to provide continuous treatment rather than on-demand dosing for men with erectile dysfunction.
Tadalafil once a day is used for the treatment of erectile dysfunction in adult men. It is a once-daily oral regimen studied in a Phase 3 trial that enrolled 378 men aged 18 years and older. The trial evaluated whether daily dosing could improve psychological outcomes in patients with erectile dysfunction.
Tadalafil once a day targets PDE5A, also known as phosphodiesterase type 5. It acts as an inhibitor of this enzyme. By inhibiting PDE5A, the drug affects the cyclic GMP pathway involved in penile smooth muscle relaxation and erectile function. This mechanism underlies its use in erectile dysfunction.
Tadalafil once a day is developed by Eli Lilly and Company, which trades under the ticker LLY. Lilly is the sponsor of the clinical program evaluating this once-daily tadalafil regimen for erectile dysfunction.
Tadalafil once a day is in Phase 3 development. It is investigational and has not been approved by the FDA for this once-daily erectile dysfunction indication. The Phase 3 program includes one completed trial, and no active trials are currently listed for this regimen.
Tadalafil once a day has been studied in the Phase 3 trial NCT00734604, titled A Study for Patients With Erectile Dysfunction to Test Whether Tadalafil Taken Once a Day Can Better Improve Psychological Outcomes. The trial is completed, enrolled 378 male participants aged 18 years and older, and was conducted across the United States, Australia, Brazil, Germany, Italy, Mexico, Puerto Rico, Spain, and the United Kingdom.
Yes, tadalafil once a day [T(OaD)] is another name for tadalafil once a day. Both refer to the same once-daily oral tadalafil regimen developed by Eli Lilly and Company for erectile dysfunction. The abbreviation T(OaD) stands for tadalafil once a day.