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AVANAFIL

Phase 3

Sexual Function and Fertility Disorders NEC-Erectile Dysfunction | Small molecule | Endocrine |Sanofi|Last Updated: Mar 17, 2016

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindPLACEBO_CONTROLLED
Total Trials1
Total Enrollment189

FDA Designations

No designations recorded

Clinical trial landscape

AVANAFIL · 1 trial · 1 indication

Phase 3 1
NCT02503306Efficacy and Tolerability Study of Avanafil in RussiaSexual Function and Fertility Disorders NEC-Erectile Dysfunction
COMPLETED189 Analytics
PHASE3COMPLETED
Efficacy and Tolerability Study of Avanafil in Russia
Sexual Function and Fertility Disorders NEC-Erectile DysfunctionUnlock trial analytics

Study Endpoints

Primary Endpoints

Change in the percentage of sexual attempts in which subjects are able to maintain an erection of sufficient duration to have successful intercourse
12 weeks
Change in the percentage of sexual attempts in which subjects are able to insert the penis into the partner's vagina
8 weeks
Change from baseline in EF score
baseline and 8 weeks

Secondary Endpoints

Change from baseline in IIEF-EF risk scores
baseline and 8 weeks
Proportion of patients with adverse events
12 weeks
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Avanafil dose 1EXPERIMENTALAdministered 30 minutes prior to initiation of sexual activity for a duration of 8 weeks to use no more than one dose in any 24-hour period
Avanafil dose 2EXPERIMENTALAdministered 30 minutes prior to initiation of sexual activity for a duration of 8 weeks to use no more than one dose in any 24-hour period
PlaceboPLACEBO_COMPARATORAdministered 30 minutes prior to initiation of sexual activity for a duration of 8 weeks to use no more than one dose in any 24-hour period

Interventions

NameTypeDescription
AVANAFILDRUGPharmaceutical form:tablets Route of administration: oral
placeboDRUGPharmaceutical form:tablets Route of administration: oral
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Eligibility Criteria

Age Range18 Years to N/A
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion criteria: * Male subjects, age ≥18 years. * Minimum 6-month history of mild to severe erectile dysfunction prior to the enrollment into the study. * Subject is in a monogamous, heterosexual relationship for at least 3 months prior to the enrollment into the study. * Subject agrees to make...

Countries:Russia
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Frequently asked questions about AVANAFIL

What is Avanafil used for?

Avanafil is used for erectile dysfunction, a sexual function and fertility disorder. It is being developed as a small molecule treatment for this condition. The drug is currently in Phase 3 clinical development and is not yet approved for use.

Who makes Avanafil?

Avanafil is being developed by Sanofi, a company traded under the ticker symbol SNY. Sanofi is conducting clinical trials to evaluate the drug's efficacy and tolerability for the treatment of erectile dysfunction.

What phase is Avanafil in?

Avanafil is in Phase 3 clinical development. It is an investigational drug, meaning it has not yet been approved by regulatory authorities. The drug is being studied for its safety and effectiveness in treating erectile dysfunction.

What clinical trials is Avanafil in?

Avanafil has one completed Phase 3 clinical trial, identified as NCT02503306. This study, titled 'Efficacy and Tolerability Study of Avanafil in Russia,' enrolled 189 male participants aged 18 years and older. The trial was randomized, double-blind, and placebo-controlled.

Is Avanafil the same as any other drug?

Avanafil is a distinct drug entity. It is not known to be the same as any other marketed medication. Its unique chemical structure and mechanism of action differentiate it from other treatments for erectile dysfunction.