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AVANAFIL

Phase 3

Sexual Function and Fertility Disorders NEC-Erectile Dysfunction | Small molecule | Other |Sanofi|Last Updated: Mar 17, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindPLACEBO_CONTROLLEDBiomarker
Total Trials1
Total Enrollment189
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02503306Efficacy and Tolerability Study of Avanafil in RussiaPHASE3 COMPLETED 189Jul 1, 2015Mar 1, 2016Mar 17, 20161 Russia
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Study Endpoints
Primary Endpoints
Change in the percentage of sexual attempts in which subjects are able to maintain an erection of sufficient duration to have successful intercourse
12 weeks
Change in the percentage of sexual attempts in which subjects are able to insert the penis into the partner's vagina
8 weeks
Change from baseline in EF score
baseline and 8 weeks
Secondary Endpoints
Change from baseline in IIEF-EF risk scores
baseline and 8 weeks
Proportion of patients with adverse events
12 weeks
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Study Design & Arms
AllocationRANDOMIZED
MaskingDOUBLE
ModelPARALLEL
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Avanafil dose 1EXPERIMENTALAdministered 30 minutes prior to initiation of sexual activity for a duration of 8 weeks to use no more than one dose in any 24-hour period
Avanafil dose 2EXPERIMENTALAdministered 30 minutes prior to initiation of sexual activity for a duration of 8 weeks to use no more than one dose in any 24-hour period
PlaceboPLACEBO_COMPARATORAdministered 30 minutes prior to initiation of sexual activity for a duration of 8 weeks to use no more than one dose in any 24-hour period
Interventions
NameTypeDescription
AVANAFILDRUGPharmaceutical form:tablets Route of administration: oral
placeboDRUGPharmaceutical form:tablets Route of administration: oral
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Eligibility Criteria
Age Range18 Years — N/A
SexMALE
Healthy VolunteersNo
Study Sites1

Inclusion criteria: * Male subjects, age ≥18 years. * Minimum 6-month history of mild to severe erectile dysfunction prior to the enrollment into the study. * Subject is in a monogamous, heterosexual relationship for at least 3 months prior to the enrollment into the study. * Subject agrees to make...

Countries:Russia
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