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tapentadol 100-mg TRF

Phase 1

Healthy Volunteer | Small molecule | Other |Johnson & Johnson|Last Updated: Mar 13, 2012

Success Probability

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Market & Valuation

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Trial Design

RandomizedCONTROLLED
Total Trials1
Total Enrollment30

FDA Designations

No designations recorded

Clinical trial landscape

tapentadol 100-mg TRF · 1 trial · 1 indication

Phase 1 1
NCT01273532A Study to Compare the Bioequivalence of 50-mg Tapentadol (CG5503) Dose Administered as Two 50-mg Tablets Relative to One 100-mg TabletHealthy Volunteer
COMPLETED30 Analytics
PHASE1COMPLETED
A Study to Compare the Bioequivalence of 50-mg Tapentadol (CG5503) Dose Administered as Two 50-mg Tablets Relative to One 100-mg Tablet
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Study Endpoints

Primary Endpoints

Pharmacokinetic profile, as measured by Cmax, tmax, AUC, t1/2, kel, AUMC and MRT
Two days

Secondary Endpoints

Number of participants with adverse events
Time of screening to end of treatment (up to 5.5 weeks)
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Study Design & Arms

AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER

Treatment Arms

ArmTypeDescription
001EXPERIMENTALtapentadol (CG5503) ER 50-mg TRF 100 mg TRF single oral dose
002EXPERIMENTALtapentadol (CG5503) ER 100-mg TRF 100mg TRF single oral dose

Interventions

NameTypeDescription
tapentadol (CG5503) ER 100-mg TRFDRUG100mg TRF single oral dose
tapentadol (CG5503) ER 50-mg TRFDRUG100 mg TRF single oral dose
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Eligibility Criteria

Age Range20 Years to 45 Years
SexMALE
Healthy VolunteersYes

Inclusion Criteria: * Japanese participants who have resided outside of Japan for no more than 5 years and whose parents and maternal and paternal grandparents are Japanese, as determined by participant's verbal report * Deemed healthy on the basis of prestudy physical examination, medical history ...

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Frequently asked questions about tapentadol 100-mg TRF

What is tapentadol 100-mg TRF?

Tapentadol 100-mg TRF is an investigational small molecule being developed by Johnson & Johnson (JNJ). It is a 100-mg tablet formulation of tapentadol, studied in healthy volunteers. The drug is in Phase 1 clinical development and is not yet approved by regulatory authorities.

What is tapentadol 100-mg TRF used for?

Tapentadol 100-mg TRF is being studied for use in healthy volunteers, specifically to assess the bioequivalence of a 50-mg dose administered as two 50-mg tablets relative to one 100-mg tablet. The indication listed is Healthy Volunteer, and it is not intended for a specific disease condition.

Who makes tapentadol 100-mg TRF?

Johnson & Johnson (JNJ) is developing tapentadol 100-mg TRF. The company is conducting clinical trials for this investigational drug, which is currently in Phase 1 development.

What phase is tapentadol 100-mg TRF in?

Tapentadol 100-mg TRF is in Phase 1 clinical development. It is an investigational drug and has not been approved by the FDA. One Phase 1 trial has been completed, and the drug is not yet available for clinical use.

What clinical trials is tapentadol 100-mg TRF in?

Tapentadol 100-mg TRF is associated with one completed Phase 1 clinical trial, NCT01273532. This study compared the bioequivalence of a 50-mg dose administered as two 50-mg tablets relative to one 100-mg tablet in 30 healthy male volunteers.

Is tapentadol 100-mg TRF the same as tapentadol?

Tapentadol 100-mg TRF is a specific tablet formulation of tapentadol, a small molecule drug. The trial NCT01273532 evaluates the bioequivalence of different tablet strengths, indicating that the 100-mg TRF is a dosage form of tapentadol.