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tapentadol 25-mg TRF

Phase 1

Healthy Volunteer | Small molecule | Other |Johnson & Johnson|Last Updated: Mar 13, 2012

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedCONTROLLEDBiomarker
Total Trials1
Total Enrollment30
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT01273506A Study to Compare the Bioequivalence of 50-mg Tapentadol (CG5503) Dose Administered as Two 25-mg Tablets Relative to One 50-mg TabletPHASE1 COMPLETED 30Dec 1, 2010Feb 1, 2011Mar 13, 2012 -
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Study Endpoints
Primary Endpoints
Pharmacokinetic profile, as measured by Cmax, tmax, AUC, t1/2, kel, AUMC, and MRT
two days
Secondary Endpoints
Number of participants with adverse events
time of screening to end of treatment (up to 5.5 weeks)
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
Treatment Arms
ArmTypeDescription
001EXPERIMENTALtapentadol (CG5503) ER 25-mg TRF 50 mg TRF single oral dose
002EXPERIMENTALtapentadol (CG5503) ER 50-mg TRF 50 mg TRF single oral dose
Interventions
NameTypeDescription
tapentadol (CG5503) ER 25-mg TRFDRUG50 mg TRF single oral dose
tapentadol (CG5503) ER 50-mg TRFDRUG50 mg TRF single oral dose
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Eligibility Criteria
Age Range20 Years — 45 Years
SexMALE
Healthy VolunteersYes

Inclusion Criteria: * Japanese participants who have resided outside of Japan for no more than 5 years and whose parents and maternal and paternal grandparents are Japanese, as determined by participant's verbal report * Deemed healthy on the basis of prestudy physical examination, medical history ...

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