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ORADUR-Methylphenidate

Phase 3

Attention Deficit Hyperactivity Disorder | Small molecule | Other |DURECT Corporation|Last Updated: Dec 15, 2021

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment64
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02704390Evaluate Long-term Safety and Efficacy of ORADUR®-Methylphenidate in Children and Adolescents With ADHDPHASE3 COMPLETED 64Jan 1, 2016Aug 1, 2019Dec 15, 20213 Taiwan
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Study Endpoints
Primary Endpoints
SNAP-IV teacher form scores in ORADUR®-Methylphenidate
24 months

Change from baseline of Swanson, Nolan, and Pelham-IV (SNAP-IV) teacher form scores

Secondary Endpoints
SNAP-IV parent form scores in ORADUR®-Methylphenidate
24 months
Remission rate in ORADUR®-Methylphenidate
24 months
Conners' Continuous Performance Test (CPT-II) performance in ORADUR®-Methylphenidate
24 months
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
ORADUR®-MethylphenidateEXPERIMENTALORADUR®-Methylphenidate oral capsule will be administered once daily in the morning for 24 months.
Interventions
NameTypeDescription
ORADUR®-MethylphenidateDRUGORADUR®-Methylphenidate is available in three dosage forms, 22 mg, 33 mg or 44 mg. Subjects will continue to receive ORADUR®-Methylphenidate at the previously determined optimal dose for 24 months.
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Eligibility Criteria
Age Range6 Years — 18 Years
SexALL
Healthy VolunteersNo
Study Sites3

Main Inclusion Criteria: 1. Subjects previously enrolled in OP-2PN012-301 study and completed 4-week study treatment 2. Both subjects and parents/guardians have provided their signed and dated informed consent form for the study Main Exclusion Criteria: 1. Subjects who experienced unmanageable ad...

Countries:Taiwan
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