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ACTR087

Phase 1

Lymphoma | Monoclonal antibody | Oncology |Cogent Biosciences, Inc.|Last Updated: Mar 31, 2020

Success Probability

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Market & Valuation

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Trial Design

UNCONTROLLEDDMC
Total Trials1
Total Enrollment34

FDA Designations

No designations recorded

Clinical trial landscape

ACTR087 · 1 trial · 1 indication

Phase 1 1
NCT02776813Study of ACTR087 in Subjects With Relapsed or Refractory B-cell LymphomaLymphoma
COMPLETED34 Analytics
PHASE1COMPLETED
Study of ACTR087 in Subjects With Relapsed or Refractory B-cell Lymphoma
LymphomaUnlock trial analytics

Study Endpoints

Primary Endpoints

Safety as assessed by dose limiting toxicities (DLTs)
28 days
Safety as assessed by determination of the maximum tolerated dose (MTD)
24 months
Safety as assessed by determination of the recommended phase 2 dose (RP2D)
24 months
Safety as assessed by and adverse events, laboratory assessments and physical examinations
24 months
Safety as assessed by mini-mental state examination (MMSE)
24 months

Secondary Endpoints

Overall response rate
24 months
Duration of response
24 months
Progression free survival
24 months
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Study Design & Arms

AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
ACTR087, in combination with rituximabEXPERIMENTAL -

Interventions

NameTypeDescription
ACTR087BIOLOGICAL -
rituximabBIOLOGICAL -
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Eligibility Criteria

Age Range18 Years to 75 Years
SexALL
Healthy VolunteersNo
Study Sites7

Inclusion Criteria: * Signed written informed consent obtained prior to study procedures * Histologically-confirmed relapsed or refractory CD20+ B-cell lymphoma of one of the following types, with documented disease progression or recurrence following the immediate prior therapy: * DLBCL, regard...

Countries:United States
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Competitive Landscape -Lymphoma 338 trials

Top 20 of 66 competitors

CompanyTickerTrialsLead PhaseDrugs
Regeneron Pharmaceuticals, Inc.REGN7PHASE3Odronextamab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine
Eli Lilly and CompanyLLY12PHASE3Pirtobrutinib, Idelalisib, Bendamustine, Rituximab
AstraZeneca PLCAZN14PHASE3Surovatamig, R-CHOP, R-CVP, BR
Merck & Co., Inc.MRK16PHASE3Nemtabrutinib, Fludarabine, Cyclophosphamide, Bendamustine, Rituximab
AbbVie, Inc.ABBV11PHASE3Venetoclax
Novartis AG Sponsored ADRNVS8PHASE3Tisagenlecleucel, Lenalidomide and rituximab in 28-day cycles for up to 12 cycles, Rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or prednisolone in 21-day cycles for 6 to 8 cycles, Lymphodepleting chemotherapy
Incyte CorporationINCY16PHASE3Tafasitamab, Lenalidomide
BeOne Medicines Ltd. Sponsored ADRONC20PHASE3BGB-16673, Bendamustine, Rituximab, Methylprednisolone, Chlorambucil
Gilead Sciences, Inc.GILD7PHASE3Axicabtagene Ciloleucel, Cyclophosphamide, Fludarabine, Lenalidomide, Rituximab
Genmab A/S Sponsored ADRGMAB18PHASE3Epcoritamab, Rituximab, Lenalidomide
Bristol-Myers Squibb CompanyBMY17PHASE3Golcadomide, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine
Johnson & JohnsonJNJ11PHASE3Ibrutinib
Pfizer Inc.PFE4PHASE3Brentuximab vedotin, Rituximab, Lenalidomide
Nurix Therapeutics, Inc.NRIX6PHASE3NX-5948, Pirtobrutinib
ADC Therapeutics LtdADCT4PHASE3Loncastuximab Tesirine, Rituximab, Gemcitabine, Oxaliplatin
Corvus Pharmaceuticals, Inc.CRVS2PHASE3Soquelitinib, Belinostat, Pralatrexate
Grifols, S.A. Sponsored ADR Class BGRFS1PHASE3Xembify
HUTCHMED (China) Limited Sponsored ADRHCM2PHASE3HMPL-760, R-GemOx
Nuvalent, Inc. Class ANUVL1PHASE3Neladalkib, Alectinib
Takeda Pharmaceutical Co. Ltd. Sponsored ADRTAK6PHASE2Brentuximab Vedotin, Cyclophosphamide, Doxorubicin, Prednisone
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Frequently asked questions about ACTR087

What is ACTR087 used for?

ACTR087 is an investigational monoclonal antibody being studied for the treatment of lymphoma, specifically in patients with relapsed or refractory B-cell lymphoma. It is currently in Phase 1 clinical development and is not yet approved by regulatory authorities.

Who makes ACTR087?

ACTR087 is being developed by Cogent Biosciences, Inc., a biopharmaceutical company traded on the stock exchange under the ticker symbol COGT. The company is conducting clinical trials to evaluate the safety and efficacy of this investigational therapy.

What phase is ACTR087 in?

ACTR087 is in Phase 1 clinical development. It is an investigational drug, meaning it has not been approved by the FDA or other regulatory agencies. The Phase 1 trial has been completed, and the drug remains under investigation for its potential use in lymphoma.

What clinical trials is ACTR087 in?

ACTR087 has been studied in one clinical trial with the identifier NCT02776813, titled "Study of ACTR087 in Subjects With Relapsed or Refractory B-cell Lymphoma." This Phase 1 trial was completed and enrolled 34 participants in the United States.

Is ACTR087 FDA approved?

No, ACTR087 is not FDA approved. It is an investigational drug currently in Phase 1 clinical development. The completed Phase 1 trial evaluated its use in relapsed or refractory B-cell lymphoma, but further studies are needed before it can be considered for regulatory approval.