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GSK drug

Phase 1

Bipolar Disorder | Small molecule | Psychiatry |Biogen Inc.|Last Updated: Oct 26, 2017

Success Probability

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Market & Valuation

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Trial Design

RandomizedDouble-BlindCONTROLLED
Total Trials1
Total Enrollment50

FDA Designations

No designations recorded

Clinical trial landscape

GSK drug · 1 trial · 1 indication

Phase 1 1
NCT00488566GSK Drug Single Dose Escalation And Their Effect On Resting Motor Threshold In Healthy VolunteersBipolar Disorder
COMPLETED50 Analytics
PHASE1COMPLETED
GSK Drug Single Dose Escalation And Their Effect On Resting Motor Threshold In Healthy Volunteers
Bipolar DisorderUnlock trial analytics

Study Endpoints

Primary Endpoints

Part1:AEs for the duration of the study;
duration of the study
ECG,vitals and MAO activity predose and upto 48h post dose;
predose and upto 48h post dose
clinical labs predose and upto 24h post dose.
predose and upto 24h post dose
PK parameters up to 48h post dose.
up to 48h post dose
Part2:Difference in rMT between pre-and post-dose and relationship with PK.
between pre-and post-dose and relationship with PK

Secondary Endpoints

Part1:Bond-Lader and body sway predose and upto 24h postdose.
predose and upto 24h postdose
Part2:AEs for the duration of the study;.
duration of the study
ECG,vitals and MAO activity predose and upto 48h postdose;
predose and upto 48h postdose
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Study Design & Arms

AllocationRANDOMIZED
MaskingDOUBLE
ModelCROSSOVER
PurposeTREATMENT

Treatment Arms

ArmTypeDescription
Part 1OTHERSingle dose escalation
Part 2OTHERPharmacodynamic assessment

Interventions

NameTypeDescription
GSK drugDRUGGSK drug
PlaceboOTHERPlacebo
LamictalOTHERPositive control
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Eligibility Criteria

Age Range18 Years to 65 Years
SexALL
Healthy VolunteersYes
Study Sites2

Part 1 Inclusion Criteria: * Healthy male subjects aged between 18 and 65 yrs and female (of non-child bearing potential) subjects aged between 18 and 50 years. Part 2 Inclusion Criteria: * right-handed healthy male subjects aged between 18 and 65 years. Parts 1 \& 2 Inclusion Criteria: * body ...

Countries:United Kingdom
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Frequently asked questions about GSK drug

What is GSK drug used for?

GSK drug is an investigational small molecule being studied for the treatment of bipolar disorder. It is currently in Phase 1 clinical development and has not been approved by regulatory authorities. The drug is being evaluated for its safety and tolerability in clinical trials.

Who is developing GSK drug?

Biogen Inc. (NASDAQ: BIIB) is the developer of GSK drug. The company is conducting clinical research on this investigational small molecule for bipolar disorder. The drug is currently in Phase 1 development.

What phase is GSK drug in?

GSK drug is in Phase 1 clinical development. It is an investigational drug and has not been approved for any use. A Phase 1 trial has been completed to evaluate the drug's effects in healthy volunteers.

What clinical trials is GSK drug in?

GSK drug has one completed Phase 1 clinical trial, identified as NCT00488566. This trial was a single dose escalation study that examined the drug's effect on resting motor threshold in healthy volunteers. The trial enrolled 50 participants in the United Kingdom.

Is GSK drug the same as any other drug?

GSK drug is the name used in clinical development for this investigational compound. No alternative names have been established for this drug in the available information. It is being developed by Biogen Inc. for bipolar disorder.