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AtriCure Bipolar System

Phase 3

Atrial Fibrillation | Unknown | Cardiovascular |AtriCure, Inc.|Last Updated: Mar 29, 2013

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
UNCONTROLLEDDMC
Total Trials1
Total Enrollment55
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00560885AtriCure Bipolar Radiofrequency Ablation of Permanent Atrial FibrillationPHASE3 COMPLETED 55Nov 1, 2007Dec 1, 2012Mar 29, 20139 United States
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Study Endpoints
Primary Endpoints
Percent of Patients Free From AF and Off Class I and III Anti-arrhythmic Drugs as Determined by Holter Monitoring at 6 Months.
6 Months Post Procedure
Composite Acute Major Adverse Event Rate, Within 30 Days Post-procedure or Hospital Discharge
30 days Post Procedure

Major Adverse Events consist of Death within 30 days or beyond 30 days if considered device related, Excessive Bleeding, Stroke, TIA or MI. A clinic visist was performed at 30 days to fully assess the patient for adverse events.

Secondary Endpoints
Percent of Patients Free From AF, Independent of Antiarrhythmic Drug Status as Determined by Holter Monitoring at 6 Months.
6 Months Post Procedure
Composite 6-month Post-procedure Major Adverse Event Rate.
6 Months Post Procedure
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Study Design & Arms
AllocationNA
MaskingNONE
ModelSINGLE_GROUP
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
AtriCure Bipolar SystemEXPERIMENTALThe AtriCure Synergy Bipolar Ablation system is used to create lesions outlined in the Maze IV procedure during a concomitant open cardiac surgical procedure.
Interventions
NameTypeDescription
AtriCure Bipolar SystemDEVICESurgical bipolar radiofrequency ablation using the AtriCure Bipolar System
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Eligibility Criteria
Age Range18 Years — N/A
SexALL
Healthy VolunteersNo
Study Sites9

Inclusion Criteria: 1. Subject is greater than or equal to 18 years of age 2. Subject has history of permanent atrial fibrillation as defined by the ACC/AHA/ESC Guidelines 3. Subject is scheduled to undergo elective on-pump cardiac surgical procedure(s) for one or more of the following: * Mitra...

Countries:United States
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