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Asenapine

Phase 2

Schizophrenia | Small molecule | Psychiatry |Amneal Pharmaceuticals, Inc.|Last Updated: Jun 27, 2014

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedACTIVE_CONTROLLEDDMCBiomarker
Total Trials1
Total Enrollment48
FDA Designations
No designations recorded
Clinical Trials (1)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT02072954Bioequivalence Fasting Study in PatientsPHASE2 COMPLETED 48Nov 1, 2013Jun 1, 2014Jun 27, 20142 India
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Study Endpoints
Primary Endpoints
AUC 0-tau
Dosing interval on day 7

The area under plasma concentration versus time curve, over the steady state dosing interval, calculated using linear trapezoidal method.

Cmax
Dosing interval on day 7

Maximum measured plasma concentration over the steady state doing interval

Secondary Endpoints
Cmin
Dosing interval on day 7
Tmax
Dosing interval on day 7
Cavg
Dosing interval on day 7
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelCROSSOVER
PurposeTREATMENT
Treatment Arms
ArmTypeDescription
Asenapine Sublingual TabletsEXPERIMENTALAsenapine Sublingual Tablets, 10 mg. Twice daily for a period of 7 days
Saphris Subligual TabletsACTIVE_COMPARATORAsenapine Sublingual Tablets, 10 mg. Twice daily for 2 periods of 7 days each.
Interventions
NameTypeDescription
Asenapine Sublingual Tablets 10 mgDRUGWhite to off-white, round, uncoated,unscored, flat-faced radius edge tablet. Debossed with A on one side and 17 on the other side
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Eligibility Criteria
Age Range18 Years — 65 Years
SexALL
Healthy VolunteersNo
Study Sites2

Inclusion Criteria: * Adult patients of either sex with age between 18 to 65 years (both inclusive) and have been taking a stable dose of asenapine maleate sublingual tablet, EQ 10 mg base twice daily therapy for at least three months. * Willing and able to comply with study visit schedule and othe...

Countries:India
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