Full Press Release Details
Leap Therapeutics Provides Update on BeiGene
Option Agreement for DKN-01
DisTinGuish Trial of DKN-01 plus tislelizumab and
chemotherapy to continue as a clinical collaboration
MA - March 16, 2023 - Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing
targeted and immuno-oncology therapeutics, today announced that BeiGene's option under the Exclusive Option and License Agreement
between Leap and BeiGene granting rights in certain Asian territories to DKN-01, Leap's anti-DKK1 monoclonal antibody, has expired
in accordance with the terms of the agreement. Leap and BeiGene will continue to collaborate on the ongoing Part C of the DisTinGuish
trial, a randomized controlled trial of DKN-01 in combination with BeiGene's anti-PD-1 antibody, tislelizumab, and chemotherapy
in first-line gastric cancer patients, as a clinical collaboration with BeiGene supplying tislelizumab. Enrollment in the 160-patient
study is expected to be completed in late 2023.
"We look forward to continuing to collaborate
with BeiGene to execute on our first randomized controlled trial for DKN-01 in first-line gastric cancer patients," said Douglas
E. Onsi, President and Chief Executive Officer of Leap. "With global rights to DKN-01 and a cash runway that was enhanced into mid-2025
by our recent acquisition of Flame Biosciences, we will look to identify a new strategic partner as we generate new clinical data from
our ongoing studies in first-line gastric cancer patients, second-line colorectal cancer patients, and an investigator-sponsored study
in endometrial cancer patients. We will also continue the development of the newly-acquired Claudin18.2 programs as part of our focus
on biomarker-targeted antibody therapies for cancer patients, particularly those with GI cancers."
About Leap Therapeutics
Leap Therapeutics (Nasdaq: LPTX) is focused on
developing targeted and immuno-oncology therapeutics. Leap's most advanced clinical candidate, DKN-01, is a humanized monoclonal
antibody targeting the Dickkopf-1 (DKK1) protein. DKN-01 is being developed in patients with esophagogastric, gynecologic, and colorectal
cancers. FL-301, is a humanized monoclonal antibody targeting Claudin18.2, being developed in patients with gastric and pancreatic cancer.
Leap also has preclinical antibody programs targeting Claudin18.2/CD137 and GDF15. For more information about Leap Therapeutics, visit
http://www.leaptx.com or view our public filings with the SEC that are available via EDGAR at http://www.sec.gov or via
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statements, other than historical facts, including statements regarding the continuation over time of our clinical collaboration with
BeiGene on the ongoing Part C of the DisTinGuish trial, with BeiGene continuing to supply tislelizumab; the enhancement of
our cash runway into mid-2025; our future development plans in connection with our newly-acquired Claudin18.2 programs; the potential,
safety, efficacy, and regulatory and clinical progress of Leap's product candidates, including the anticipated timing for enrollment
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President & Chief Executive Officer
Leap Therapeutics, Inc.