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Inactivated, Split-Virion Influenza Virus

Phase 2

Influenza | Monoclonal antibody | Infectious Disease |Sanofi|Last Updated: Apr 14, 2016

Success Probability
Approval Probability 71%
TA Base Rate26%
Adjusted LOA41%
ML RiskLOW_RISK
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Market & Valuation
rNPV $3.2B
Market Size $9.4B
Revenue Basis $1.6B
Competitors 6
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Trial Design
RandomizedDouble-BlindACTIVE_CONTROLLEDDMCBiomarker
Total Trials4
Total Enrollment1,496
FDA Designations
No designations recorded
Clinical Trials (4)
NCT IDTitlePhaseStatusEnrollmentVelocityDesignStartCompletionLast UpdatedSitesCountries
NCT00606359Immunogenicity of the Inactivated Split-Virion Influenza Vaccine in Renal Transplant SubjectsPHASE2 COMPLETED 62Nov 1, 2007Jun 1, 2008Jan 14, 20141 France
NCT00776438Study of Immune Response in Adults and Elderly Subjects Vaccinated With Inactivated Influenza VaccinesPHASE2 COMPLETED 160Sep 1, 2007Apr 1, 2009Jun 17, 20151 France
NCT00524940Trial to Describe the Safety and Immunogenicity of Fluzone®PHASE2 COMPLETED 124Aug 1, 2007Dec 1, 2007Apr 14, 20161 United States
NCT00703651Study of Inactivated, Split-Virion Influenza Vaccine Administered by Intradermal Route Versus Vaxigrip® in AdultsPHASE2 COMPLETED 1,150Sep 1, 2003Jul 1, 2006Jan 13, 20148 Belgium, Czechia +1
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Study Endpoints
Primary Endpoints
Anti-HA individual titers
21 Days Post-vaccination 2
Individual titers ratio
21 Days Post-vaccination 2
Seroconversion or significant increase
21 Days Post-vaccination 2
To provide information concerning immune response to an inactivated, split-virion, influenza vaccine.
21 days post-vaccination
To provide information concerning the safety of inactivated, split-virion, influenza vaccine.
21 days post-vaccination and entire study duration
Solicited Injection Site and Solicited Systemic Reactions Post-vaccination.
0-3 days post-vaccination and entire study duration

Information concerning the safety of Fluzone® vaccine 2007-2008 formulation.

Geometric Mean Titers (GMTs) of Hemagglutination Inhibition Antibodies Pre-vaccination and Post-vaccination.
21 days post-vaccination

GMTs and their 95% Confidence Interval are presented for each of the 3 antigens in the Fluzone® Vaccine 2007-2008 formulation.

To provide information concerning the immunogenicity of Inactivated, Split-Virion Influenza Vaccine.
21days post-vaccination
To provide information concerning the safety of Inactivated, Split-Virion Influenza Vaccine
21 days post-vaccination and entire study duration
Secondary Endpoints
Safety: Adverse events in the first 21 days after each vaccination; Pre-listed reactions in the 7 days following each vaccination; Serious adverse events during the entire trial.
21 days following each vaccination
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Study Design & Arms
AllocationRANDOMIZED
MaskingNONE
ModelPARALLEL
PurposePREVENTION
Treatment Arms
ArmTypeDescription
Study Group 1EXPERIMENTAL -
Study Group 2ACTIVE_COMPARATOR -
Study Group 3EXPERIMENTALElderly, age 60 to 85 years
Study Group 4EXPERIMENTALElderly, age 60 to 85 years
Study GroupEXPERIMENTAL -
1EXPERIMENTAL -
2EXPERIMENTAL -
3ACTIVE_COMPARATOR -
Interventions
NameTypeDescription
Inactivated, split-virion influenza virusBIOLOGICAL0.1 mL, Intradermal. 2 vaccinations 12 months apart
Inactivated, split-virion, influenza vaccineBIOLOGICAL0.1 mL, Intradermal
Inactivated, split-virion influenza vaccineBIOLOGICAL0.1 mL, Intradermal
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Eligibility Criteria
Age Range18 Years — 60 Years
SexALL
Healthy VolunteersYes
Study Sites1

Inclusion Criteria: * Able to attend all scheduled visits and to comply with all trial procedures. * Subject with renal transplant for at least 6 months. * Subject with stable renal function, i.e. with a variation of creatinin value \< 20% and with a creatinin clearance estimated according to Cockr...

Countries:FranceUnited StatesBelgiumCzechiaLithuania
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